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Titolo:
CARCINOEMBRYONIC ANTIGEN IN HUMAN COLONIC ABERRANT CRYPT FOCI
Autore:
PRETLOW TP; ROUKHADZE EV; ORIORDAN MA; CHAN JC; AMINI SB; STELLATO TA;
Indirizzi:
CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT PATHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT EPIDEMIOL & BIOSTAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT SURG CLEVELAND OH 44106 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL HOUSTON TX 77030
Titolo Testata:
Gastroenterology
fascicolo: 6, volume: 107, anno: 1994,
pagine: 1719 - 1725
SICI:
0016-5085(1994)107:6<1719:CAIHCA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE PRENEOPLASTIC LESIONS; HEXOSAMINIDASE ACTIVITY; MURINE COLON; F344 RATS; LOCALIZATION; TISSUES; CANCER; QUANTIFICATION; MICROADENOMAS; CARCINOGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T.P. Pretlow et al., "CARCINOEMBRYONIC ANTIGEN IN HUMAN COLONIC ABERRANT CRYPT FOCI", Gastroenterology, 107(6), 1994, pp. 1719-1725

Abstract

Background/Aims: Aberrant crypt foci are putative preneoplastic lesions that, by definition, are identified microscopically in whole-mount preparations of colonic mucosa. Because the identification of hexosaminidase as a marker for rat aberrant crypt foci in histological sections facilitated their characterization, a similar marker for human foci in histological sections was sought. Methods: Human aberrant crypt foci were marked in whole-mount preparations, embedded in paraffin, and evaluated for their expression of carcinoembryonic antigen with two monoclonal antibodies. Results: Elevated expression of carcinoembryonic antigen was detected in 39 of 42 (93%) aberrant crypt foci from 15 patients. The expression of carcinoembryonic antigen assisted in the evaluation of longitudinal sections of foci, where dysplasia is more readily detected in these small lesions. The expression of carcinoembryonic antigen was related to the sizes of the foci (P = 0.0085, generalized Fisher's Exact Test) but not to the presence or degree of dysplasia. Conclusions: The overexpression of immunohistochemically demonstrable carcinoembryonic antigen is, to date, the only described alteration in most of these putative precursors of human colon cancer that differs from the expression in contiguous, normal crypts at the histological level and thus facilitates the identification of aberrant crypts in histological sections for further characterization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:28:58