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Titolo:
A DIAMINOANTHRAQUINONE INHIBITOR OF ANGIOGENESIS
Autore:
TAKANO S; GATELY S; JIANG JB; BREM S;
Indirizzi:
NW MEM HOSP,DIV NEUROL SURG,233 E ERIE ST,SUITE 500 CHICAGO IL 60611 NW MEM HOSP,DIV NEUROL SURG CHICAGO IL 60611 SCH MED CHICAGO CHICAGO IL 00000 SPHINX PHARMACEUT CORP DURHAM NC 00000
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 271, anno: 1994,
pagine: 1027 - 1033
SICI:
0022-3565(1994)271:2<1027:ADIOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; PROTEIN-KINASE-C; CAPILLARY ENDOTHELIAL-CELLS; PLASMINOGEN-ACTIVATOR PRODUCTION; INTERSTITIAL COLLAGENASE; DNA-SYNTHESIS; IDENTIFICATION; EXPRESSION; INVASION; METALLOPROTEINASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S. Takano et al., "A DIAMINOANTHRAQUINONE INHIBITOR OF ANGIOGENESIS", The Journal of pharmacology and experimental therapeutics, 271(2), 1994, pp. 1027-1033

Abstract

Tumor growth is dependent upon angiogenesis. There is an intense search for pharmacological inhibitors of angiogenesis as a novel approach to treat angiogenic diseases, e.g., arthritis, diabetic retinopathy orcancer. A series of compounds, originally studied as potential protein kinase C inhibitors, included the diaminoanthraquinone NSC 639366 amino)-2-hydroxypropyl]amino]-4-[(2,3-epoxypropyl) amino]-9,10-anthracenedione fumaric acid salt} (SPC-100097), was found to reversibly inhibit bovine endothelial cell growth with an IC50 that ranged between 1 and 4 nM. NSC 639366 reversibly inhibited endothelial cell migration, particularly endothelial cells stimulated by the potent angiogenic molecule, basic fibroblast growth factor. The activity of secreted urokinase-type plasminogen activator and active interstitial collagenase, but not gelatinase, was inhibited by NSC 639366. In vivo, angiogenesis wassignificantly inhibited by NSC 639366 by using the chick chorioallantoic membrane or the rat corneal bioassay. Two analogs of NSC 639366 did not inhibit endothelial cell growth. These experiments introduce a novel compound that could be clinically useful against angiogenic diseases and encourage further development of compounds that inhibit the plasminogen-plasmin system known to be a key regulator of angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:42:31