Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
METABOLIC DISPOSITION OF IMIPRAMINE IN ORIENTAL SUBJECTS - RELATION TO METOPROLOL ALPHA-HYDROXYLATION AND S-MEPHENYTOIN 4'-HYDROXYLATION PHENOTYPES
Autore:
KOYAMA E; SOHN DR; SHIN SG; CHIBA K; SHIN JG; KIM YH; ECHIZEN H; ISHIZAKI T;
Indirizzi:
INT MED CTR JAPAN,RES INST,DEPT CLIN PHARMACOL,SHINJUKU KU,TOYAMA 1-21-2 TOKYO 162 JAPAN INT MED CTR JAPAN,RES INST,DEPT CLIN PHARMACOL,SHINJUKU KU TOKYO 162 JAPAN GYEONGSANG NATL UNIV,COLL MED,DEPT PHARMACOL CHINJU SOUTH KOREA SEOUL NATL UNIV HOSP,COLL MED,DEPT PHARMACOL,CLIN PHARMACOL UNIT SEOUL 110744 SOUTH KOREA INJE UNIV HOSP,COLL MED,DEPT PSYCHIAT PUSAN SOUTH KOREA NATL INST HLTH & NUTR,DIV GERIATR HLTH & NUTR TOKYO 162 JAPAN
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 271, anno: 1994,
pagine: 860 - 867
SICI:
0022-3565(1994)271:2<860:MDOIIO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPARTEINE OXIDATION PHENOTYPE; HUMAN-LIVER-MICROSOMES; CLINICAL PHARMACOKINETICS; INTERETHNIC DIFFERENCES; LIQUID-CHROMATOGRAPHY; GENETIC-POLYMORPHISM; DIAZEPAM METABOLISM; JAPANESE POPULATION; NATIVE CHINESE; HUMAN-PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
E. Koyama et al., "METABOLIC DISPOSITION OF IMIPRAMINE IN ORIENTAL SUBJECTS - RELATION TO METOPROLOL ALPHA-HYDROXYLATION AND S-MEPHENYTOIN 4'-HYDROXYLATION PHENOTYPES", The Journal of pharmacology and experimental therapeutics, 271(2), 1994, pp. 860-867

Abstract

We studied the metabolic disposition of imipramine by measuring imipramine and its metabolites in plasma and urine simultaneously after a single oral dose of 25 mg of imipramine hydrochloride administered to 16 healthy (three Japanese and 13 Korean volunteers. Four of the subjects were poor metabolizers (PMs) of metoprolol but extensive metabolizers (EMs) of S-mephenytoin (PM(ML)/EM(MP)), five subjects were EMs of metoprolol but PMs of S-mephenytoin (EM(ML)/PM(MP)) and seven subjects were EMs of both metoprolol and S-mephenytoin (EM(ML)/EM(MP)). The mean (+/- S.D.) oral clearances of imipramine were smaller in the PM(ML)/EM(MP) group and the EM(MP)/PM(MP) group than in the EM(ML)/EM(MP) group, although a statistical difference (P < .05) was found only in th EM(ML)/PM(MP) vs. the EM(ML)/EM(MP) group. The mean area under the plasma concentration-time curve (AUC) of desipramine was 9 times greater (p < .01) in PM(ML)/EM(MP) group, whereas the mean value was 0.6 times smaller (P < .05) in the EM(ML)/PM(MP) group than in the EM(ML)/EM(MP)group. The log(10) metoprolol/alpha-hydroxymetoprolol ratio correlated positively with the AUC of desipramine (P < .01) and with the AUC ratio of desipramine/imipramine (P < .05) but negatively with the AUC ratio of desipramine/imipramine (P < .05). Log(10) percent 4'-hydroxymephenytoin excreted in 8-hr urine correlated positively with the AUC of desipramine (P < .01) and with the AUC ratio of despiramine/imipramine(P < .01). The urinary excretions of imipramine and its metabolites also reflected the data derived from plasma samples in the three different phenotype-paired panels. The results suggest that the 2-hydroxylation and the N-demethylation of imipramine metabolism are under a pharmacogenetic control of debrisoquin- and S-mephenytoin-type oxidation, respectively, in Oriental subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:49:24