Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CYCLIC ADP-RIBOSE - A CALCIUM MOBILIZING METABOLITE OF NAD(+)
Autore:
LEE HC;
Indirizzi:
UNIV MINNESOTA,DEPT PHYSIOL,LYON LAB 6 182 MINNEAPOLIS MN 55455
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 138, anno: 1994,
pagine: 229 - 235
SICI:
0300-8177(1994)138:1-2<229:CA-ACM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEA-URCHIN EGGS; INDUCED CA2+ RELEASE; INOSITOL TRISPHOSPHATE; 2ND-MESSENGER ENZYME; FERTILIZATION; MICROSOMES; RYANODINE; CA-2+; CELLS; NAD+;
Keywords:
CYCLIC ADP-RIBOSE; INOSITOL 1,4,5-TRISPHOSPHATE; CA+2-INDUCED CA+2 RELEASE; CA+2 MOBILIZATION; ADP-RIBOSYL CYCLASE; CD38; CYCLIC ADP-RIBOSE HYDROLASE; CYCLIC ADP-RIBOSE RECEPTOR; RYANODINE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
H.C. Lee, "CYCLIC ADP-RIBOSE - A CALCIUM MOBILIZING METABOLITE OF NAD(+)", Molecular and cellular biochemistry, 138(1-2), 1994, pp. 229-235

Abstract

Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD(+) called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate inmobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved inits metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 12:33:49