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Titolo:
FISSION YEAST CUT5 LINKS NUCLEAR CHROMATIN AND M-PHASE REGULATOR IN THE REPLICATION CHECKPOINT CONTROL
Autore:
SAKA Y; FANTES P; SUTANI T; MCINERNY C; CREANOR J; YANAGIDA M;
Indirizzi:
KYOTO UNIV,FAC SCI,DEPT BIOPHYS,SAKYO KU,KITASHIRAKAWA OIWAKECHO KYOTO 606 JAPAN KYOTO UNIV,FAC SCI,DEPT BIOPHYS,SAKYO KU KYOTO 606 JAPAN INST CELL & MOLEC BIOL EDINBURGH EH9 3JR MIDLOTHIAN SCOTLAND UNIV EDINBURGH,INST CELL ANIM & POPULAT BIOL EDINBURGH EH9 3JT MIDLOTHIAN SCOTLAND
Titolo Testata:
EMBO journal
fascicolo: 22, volume: 13, anno: 1994,
pagine: 5319 - 5329
SICI:
0261-4189(1994)13:22<5319:FYCLNC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DIVISION CYCLE; HUMAN XRCC1 GENE; SCHIZOSACCHAROMYCES-POMBE; DNA-REPLICATION; S-PHASE; CHROMOSOME-REPLICATION; SEQUENCE SIMILARITY; SPINDLE FORMATION; REPAIR GENE; MITOSIS;
Keywords:
CHECKPOINT CONTROL; MITOSIS; PROTOONCOGENE; REPLICATION; SCHIZOSACCHAROMYCES POMBE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
Y. Saka et al., "FISSION YEAST CUT5 LINKS NUCLEAR CHROMATIN AND M-PHASE REGULATOR IN THE REPLICATION CHECKPOINT CONTROL", EMBO journal, 13(22), 1994, pp. 5319-5329

Abstract

Fission yeast temperature-sensitive cut5 (cell untimely torn) mutantsare defective in initiation and/or elongation of DNA replication but allow mitosis and cell division at a restrictive temperature. We show that the cut5 protein (identical to rad4) (i) is an essential component of the replication checkpoint system but not the DNA damage checkpoint, and (ii) negatively regulates the activation of M phase kinase at mitotic entry. Even if the replication checkpoint has been activated previously, cut5 mutations allow mitosis and cell division after shift to 36 degrees C. Transcription of cut5(+) is not under the control of the START gene cdc10(+) The cut5 protein is enriched in the nucleus, consisting of repeating domains. An essential domain which resembles the proto-oncoprotein Ect2 has a strong negative effect on the entry into mitosis when overexpressed. Expression of the cut5 mutant phenotype requires the function of the M phase regulator genes cdc2(+), cdc25(+)and cdc13(+). The cut5 protein forms a novel, essential link between DNA synthesis and M phase activation in the replication checkpoint control pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:03:20