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Titolo:
REDUCED EXPRESSION OF CELLULAR FOS GENE IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS
Autore:
OGINO H; INAGAKI Y; MORIOKA T; KAWAI H; UNOURA M; NAKANUMA Y; KOBAYASHI K;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 1,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT PATHOL 2 KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 6, volume: 2, anno: 1994,
pagine: 367 - 374
SICI:
1386-6346(1994)2:6<367:REOCFG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
URSODEOXYCHOLIC ACID; ONCOGENE EXPRESSION; RNA; LYMPHOCYTES; AUTOIMMUNE; THERAPY;
Keywords:
PRIMARY BILIARY CIRRHOSIS; CELLULAR ONCOGENE; C-FOS GENE; URSODEOXYCHOLIC ACID THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
H. Ogino et al., "REDUCED EXPRESSION OF CELLULAR FOS GENE IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS", HEPATOLOGY RESEARCH, 2(6), 1994, pp. 367-374

Abstract

Abnormal expression of certain cellular oncogenes in peripheral bloodmononuclear cells (PBMC) is associated with several autoimmune disorders and is thought to reflect a pathologically activated state in various lymphocytic subpopulations. Using the Northern blot hybridization technique, we studied the expression of cellular (c-)fos, c-myc and N-ras genes in PBMC isolated from patients with primary biliary cirrhosis (PBC) and normal control subjects. The expression of c-fos gene was reduced significantly in patients with PBC, while there was no significant difference between the two groups in the expression of c-myc and N-ras genes. Stimulation of PBMC with mitogens in vitro increased c-fos gene expression markedly to a similar extent in both normal subjectsand in patients with PBC. Furthermore, the reduced expression of c-fos gene recovered significantly in all the patients examined after treatment with ursodeoxycholic acid (UDCA). These results suggest that thereduced expression of c-fos gene in PBMC is a reversible functional manifestation of PBC and that UDCA therapy for PBC may improve abnormallymphocyte function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:04:38