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Titolo:
DIRECT GENE-TRANSFER INTO MUSCLE
Autore:
DANKO I; WOLFF JA;
Indirizzi:
UNIV WISCONSIN,WAISMAN CTR,DEPT PEDIAT MADISON WI 53705 UNIV WISCONSIN,WAISMAN CTR,DEPT MED GENET MADISON WI 53705 UNIV WISCONSIN,WAISMAN CTR,DEPT NEUROL MADISON WI 53705
Titolo Testata:
Vaccine
fascicolo: 16, volume: 12, anno: 1994,
pagine: 1499 - 1502
SICI:
0264-410X(1994)12:16<1499:DGIM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE MUSCLE; EXPRESSION; DNA; CELLS; LONG; VECTORS; INVIVO; MICE;
Keywords:
PLASMID DNA; GENE TRANSFER; GENE EXPRESSION; GENE THERAPY; LUCIFERASE; BETA-GALACTOSIDASE; VACCINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
I. Danko e J.A. Wolff, "DIRECT GENE-TRANSFER INTO MUSCLE", Vaccine, 12(16), 1994, pp. 1499-1502

Abstract

Gene therapy has great promise for the treatment and the prevention of a broad range of inherited and acquired diseases. Gene transfer methods currently explored include the use of viral vectors and physical-chemical methods. Plasmid DNA can be taken up by skeletal muscle cells in vivo without any special delivery mechanism and persist long-term in an extrachromosomal, non-replicative circular form. Thus, foreign genes can be expressed permanently in skeletal muscle. Ar present the efficiency of gene transfer is not high enough to treat genetic muscle diseases. However, even at the relatively low efficiency of expression we are able to achieve at present, plasmid DNA transfer seems to be a very promising way of programming cells in vivo to secrete proteins for immunization purposes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:21:43