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Titolo:
CROSS-RESISTANCE PHENOTYPES OF FLUCONAZOLE-RESISTANT CANDIDA SPECIES - RESULTS WITH 655 CLINICAL ISOLATES WITH DIFFERENT METHODS
Autore:
STEVENS DA; STEVENS JA;
Indirizzi:
SANTA CLARA VALLEY MED CTR,DEPT MED,751 S BASCOM AVE SAN JOSE CA 95128 CALIF INST MED RES SAN JOSE CA 95128 STANFORD UNIV,DIV INFECT DIS & GEOG MED STANFORD CA 94305
Titolo Testata:
Diagnostic microbiology and infectious disease
fascicolo: 3-4, volume: 26, anno: 1996,
pagine: 145 - 148
SICI:
0732-8893(1996)26:3-4<145:CPOFCS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHOTERICIN-B; SUSCEPTIBILITY TEST; ANTIFUNGAL; ITRACONAZOLE; NEUTROPENIA; TRIAL; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Stevens e J.A. Stevens, "CROSS-RESISTANCE PHENOTYPES OF FLUCONAZOLE-RESISTANT CANDIDA SPECIES - RESULTS WITH 655 CLINICAL ISOLATES WITH DIFFERENT METHODS", Diagnostic microbiology and infectious disease, 26(3-4), 1996, pp. 145-148

Abstract

Candida species test results with two broth macrodilution antifungal susceptibility methods were compared using 655 clinical isolates, and the frequency of fluconazole resistance and phenotypes of azole cross resistance are detailed. A method with an 80% inhibition endpoint (as compared to clear tube endpoint) suggested greater fluconazole susceptibility to C. albicans but had a less pronounced effect on C. glabrata, and seemed to have a negligible influence on results with C. parapsilosis and C. tropicalis. The latter were grouped as susceptible and resistant (based on achievable blood levels), respectively, by both methods. Cross resistance was method dependent and more pronounced with itraconazole than ketoconazole. In vivo correlations are needed to validate the groupings proposed by any in vitro method. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:51:12