Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LOCALIZATION OF MESSENGER-RNA FOR BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN PLACENTA
Autore:
SHAMS M; AHMED A;
Indirizzi:
UNIV BIRMINGHAM,BIRMINGHAM MATERN HOSP,DEPT OBSTET & GYNAECOL BIRMINGHAM B15 2TG W MIDLANDS ENGLAND UNIV BIRMINGHAM,SCH MED,CCRIS,REPROD BIOL GRP BIRMINGHAM B15 2TT W MIDLANDS ENGLAND
Titolo Testata:
Growth factors
fascicolo: 2, volume: 11, anno: 1994,
pagine: 105 - 111
SICI:
0897-7194(1994)11:2<105:LOMFBF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; CAPILLARY ENDOTHELIAL-CELLS; HUMAN AMNION; EXPRESSION; PROTEIN; HORMONE; MATURATION; PITUITARY; INDUCTION; INVITRO;
Keywords:
HUMAN PLACENTA; TROPHOBLAST; AMNION; BASIC FGF AND IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Shams e A. Ahmed, "LOCALIZATION OF MESSENGER-RNA FOR BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN PLACENTA", Growth factors, 11(2), 1994, pp. 105-111

Abstract

The site of basic fibroblast growth factor (bFGF) gene expression in human placenta is not known. In situ hybridization using [S-35]-labelled riboprobe was employed to localize the sites of expression of bFGF mRNA in placental sections from early and late gestation. Autoradiographic hybridization signal was present in all placental tissue examined, with no significant hybridization with sense control. Basic FGF expression was seen in the syncytiotrophoblast surrounding the placental villi and in or around cytotrophoblast cells in first trimester placenta. At term, the bFGF gene expression was detected in the syncytiotrophoblast and fetal membranes. Strong expression of bFGF mRNA was localized in the smooth muscle cells around the mid and large sized placentalvessels. The detection of bFGF mRNA in the placenta during early pregnancy suggests a role for bFGF in angiogenesis, whereas, its expression at term suggests that bFGF may be associated with differentiated functions of the trophoblast.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:43:06