Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF CALCIUM-ANTAGONISTS ON ISOLATED AORTA FROM HYPERCHOLESTEROLEMIC YOSHIDA RATS OF DIFFERENT AGES
Autore:
RAGAZZI E; CHINELLATO A; PANDOLFO L; FROLDI G; CAPARROTTA L; FASSINA G;
Indirizzi:
UNIV PADUA,DEPT PHARMACOL,LARGO E MENEGHETTI 2 I-35131 PADUA ITALY
Titolo Testata:
General pharmacology
fascicolo: 7, volume: 25, anno: 1994,
pagine: 1321 - 1327
SICI:
0306-3623(1994)25:7<1321:EOCOIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; CHOLESTEROL-FED RABBIT; EAR ARTERY; ATHEROGENESIS; NIFEDIPINE; ATHEROSCLEROSIS; LIPOPROTEINS; RELAXATION; RESPONSES; CHANNELS;
Keywords:
CALCIUM ANTAGONISTS; HYPERCHOLESTEROLEMIC YOSHIDA RAT; AGING; VESSELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
E. Ragazzi et al., "EFFECT OF CALCIUM-ANTAGONISTS ON ISOLATED AORTA FROM HYPERCHOLESTEROLEMIC YOSHIDA RATS OF DIFFERENT AGES", General pharmacology, 25(7), 1994, pp. 1321-1327

Abstract

1. The in vitro thoracic aorta, precontracted with norepinephrine, KCl or PGF(2 alpha) of hypercholesterolemic Pittsburg-Yoshida (YOS) and normolipidemic Brown-Norway (BN) rats of two age groups (2 and 18 months), was relaxed by the calcium antagonists verapamil and nifedipine without any difference between age-matched YOS and BN rats. 2. The relaxant activity of verapamil was impaired in aged rats of both strains and with the different contractile agents. Conversely, no variation with aging of the nifedipine relaxing effect was observed on norepinephrine- and PGF(2 alpha)-precontracted aortic preparations both in BN and YOS rats; only on KCl-induced contraction was the nifedipine relaxant effect differently affected by age, both in YOS and BN rats. 3. In conclusion, prolonged exposure to hypercholesterolemia in YOS rat does not affect aortic response to nifedipine and verapamil. Only the aging process was able to affect vascular relaxation to calcium antagonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:41:22