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Titolo:
SPONTANEOUS COMPLETE REGRESSION OF HIGH-GRADE NON-HODGKINS-LYMPHOMA -MORPHOLOGIC, IMMUNOHISTOCHEMICAL, AND GENE AMPLIFICATION ANALYSES
Autore:
KUMAMOTO M; NAKAMINE H; HARA T; YOKOYA Y; KAWAI J; ITO H; NISHIOKA S; TAKENAKA T; WICKERT RS; MITCHELL DW;
Indirizzi:
WAKAYAMA MED UNIV,DEPT LAB MED,27,7-BANCHO WAKAYAMA 640 JAPAN WAKAYAMA MED UNIV,DEPT LAB MED WAKAYAMA 640 JAPAN WAKAYAMA MED UNIV,DEPT INTERNAL MED 2 WAKAYAMA 640 JAPAN UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL OMAHA NE 00000
Titolo Testata:
Cancer
fascicolo: 11, volume: 74, anno: 1994,
pagine: 3023 - 3028
SICI:
0008-543X(1994)74:11<3023:SCROHN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; POLYMERASE CHAIN-REACTION; SEVERE COMBINED IMMUNODEFICIENCY; LARGE CELL LYMPHOMA; SPONTANEOUS REMISSION; MALIGNANT-LYMPHOMA; SECTIONS; MODEL; MICE;
Keywords:
NON-HODGKINS LYMPHOMA; HIGH GRADE LYMPHOMA; IMMUNOBLASTIC LYMPHOMA; SPONTANEOUS REGRESSION; CLONALITY; POLYMERASE CHAIN REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Kumamoto et al., "SPONTANEOUS COMPLETE REGRESSION OF HIGH-GRADE NON-HODGKINS-LYMPHOMA -MORPHOLOGIC, IMMUNOHISTOCHEMICAL, AND GENE AMPLIFICATION ANALYSES", Cancer, 74(11), 1994, pp. 3023-3028

Abstract

Background. Spontaneous regression of non-Hodgkin's lymphoma, occasionally reported in low grade groups, is a rare phenomenon in high gradegroups. Clonal proliferation has not been confirmed in the majority of reported cases. In this woman, age 58 years, who had been diagnosed as having high grade immunoblastic lymphoma after excision of a singlecervical lymph node, the remaining bilateral cervical, inguinal, and axillary adenopathy regressed completely without any cytotoxic treatments 22 days after biopsy. At the time of this writing, the patient hasbeen free of disease for 24 months. Methods. Clonality of the lymphoproliferation in the case was examined by immunohistochemistry and polymerase chain reaction (PCR) amplification using paraffin embedded biopsy material. possible implications of Epstein-Barr virus in the pathogenesis of this process was examined also by PCR amplification and in situ hybridization. Results. The proliferating lymphoid cells showed restricted expression of immunoglobulin (Ig) light chain and amplification of clonally rearranged V-D-J regions of Ig heavy chain gene. Epstein-Barr virus did not appear to be involved in the process. Conclusion. The present study shows that spontaneous complete regression of clonal lymphoproliferation that is morphologically a high grade lymphoma can occur.

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Documento generato il 07/08/20 alle ore 05:52:12