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Titolo:
INCREASED PLASMA-LEVELS OF PAI-1 AFTER ADMINISTRATION OF NONIONIC CONTRAST-MEDIUM IN PATIENTS UNDERGOING PULMONARY ANGIOGRAPHY
Autore:
VANBEEK EJR; LEVI M; REEKERS JA; HACK CE; BULLER HR; TENCATE JW;
Indirizzi:
UNIV AMSTERDAM,ACAD MED CTR,CTR HEMOSTASIS TRROMBOSIS ATHEROSCLEROSISIMFLAMM,MEIBERGDREEF 9 1105 AZ AMSTERDAM NETHERLANDS NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB AMSTERDAM NETHERLANDS
Titolo Testata:
Radiology
fascicolo: 3, volume: 193, anno: 1994,
pagine: 821 - 823
SICI:
0033-8419(1994)193:3<821:IPOPAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR; CORONARY ANGIOPLASTY; THROMBOSIS; BLOOD; COMPLICATIONS; INHIBITOR; AGENTS; FIBRINOLYSIS; VENOGRAPHY; MIXTURES;
Keywords:
ANGIOGRAPHY, CONTRAST MEDIA; BLOOD, COAGULATION; CONTRAST MEDIA, COMPLICATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
E.J.R. Vanbeek et al., "INCREASED PLASMA-LEVELS OF PAI-1 AFTER ADMINISTRATION OF NONIONIC CONTRAST-MEDIUM IN PATIENTS UNDERGOING PULMONARY ANGIOGRAPHY", Radiology, 193(3), 1994, pp. 821-823

Abstract

PURPOSE: To compare the effects of ionic and nonionic contrast media on markers of the coagulation, fibrinolytic, and contact systems. MATERIALS AND METHODS: Low-osmolar ionic (ioxaglate) or nonionic (iohexol)contrast material was administered to 14 patients undergoing pulmonary angiography for suspected pulmonary embolism. Blood samples were obtained before and after the procedure and were analyzed for fibrinolysis and coagulation indicators such as plasminogen activator type 1 (PAI-1) activity, thrombin-antithrombin III (TAT) complexes, and platelet activation. RESULTS: Both contrast agents caused a significant increase in TAT complexes. PAI-1 levels increased significantly in patients who received iohexol but not in those who received ioxaglate. Platelet activation was more pronounced in patients who received iohexol. CONCLUSION: The increase in PAI-1 levels in response to iohexol may explainclinical differences in postprocedural thrombogenicity in patients who undergo angiography.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:58:06