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Titolo:
CONTINUOUS INTRACEREBROVENTRICULAR ADMINISTRATION OF A CORTICOTROPIN-RELEASING HORMONE ANTAGONIST AMPLIFIES SPONTANEOUS GROWTH-HORMONE PULSES IN THE RAT
Autore:
MOUNIER F; PELLEGRINI E; KORDON C; EPELBAUM J; BLUETPAJOT MT;
Indirizzi:
INSERM,U159,UNITE RECH DYNAM SYST NEUROENDOCRINIENS,2TER RUE ALESIA F-75014 PARIS FRANCE INSERM,U159,UNITE RECH DYNAM SYST NEUROENDOCRINIENS F-75014 PARIS FRANCE
Titolo Testata:
Journal of Endocrinology
fascicolo: 3, volume: 152, anno: 1997,
pagine: 431 - 436
SICI:
0022-0795(1997)152:3<431:CIAOAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSTATIN SECRETION; FACTOR RECEPTORS; PITUITARY; CELLS; BRAIN; ADRENALECTOMY; HYPOTHALAMUS; INVOLVEMENT; INHIBITION; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
F. Mounier et al., "CONTINUOUS INTRACEREBROVENTRICULAR ADMINISTRATION OF A CORTICOTROPIN-RELEASING HORMONE ANTAGONIST AMPLIFIES SPONTANEOUS GROWTH-HORMONE PULSES IN THE RAT", Journal of Endocrinology, 152(3), 1997, pp. 431-436

Abstract

Involvement of endogenous corticotropin releasing hormone (CRH) in the regulation of spontaneous growth hormone (GH) secretion was investigated. A CRH antagonist, ct helical CRH 9-41, was intracerebroventricularly infused for 36 h at a rate of 1 mu g/0.5 mu l/h to freely moving,cannulated adult male rats. Serial blood samples were drawn every 20 min for the last 8 hours of a helical CRH 9-41 infusion. The treatmentinduced a marked increase in GH peak amplitude without affecting either trough levels or numbers of peaks. In parallel, levels of growth hormone releasing hormone (GHRH) mRNA in the arcuate nucleus, but not ofsomatotropin release inhibiting hormone (SRIH) mRNA in the periventricular and arcuate nuclei, were increased. These data suggest that, in addition to its action in the stress-induced inhibition of GH secretion through regulation of periventricular SRIH neurons, CRH can also actas a modulator of endogenous GH secretion through regulation of arcuate GHRH neurons. Whether the modulatory effects of CRH on GHRH neuronsare direct or indirect remains to be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:44:27