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Titolo:
MICROALBUMINURIA AND BODY-FAT DISTRIBUTION IN OBESE SUBJECTS
Autore:
BASDEVANT A; CASSUTO D; GIBAULT T; RAISON J; GUYGRAND B;
Indirizzi:
HOP HOTEL DIEU,DEPT INTERNAL MED & NUTR F-75181 PARIS 04 FRANCE
Titolo Testata:
International journal of obesity
fascicolo: 12, volume: 18, anno: 1994,
pagine: 806 - 811
SICI:
0307-0565(1994)18:12<806:MABDIO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR INJURY; DISEASE;
Keywords:
OBESITY; BODY FAT DISTRIBUTION; INSULIN RESISTANCE; MICROALBUMINURIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A. Basdevant et al., "MICROALBUMINURIA AND BODY-FAT DISTRIBUTION IN OBESE SUBJECTS", International journal of obesity, 18(12), 1994, pp. 806-811

Abstract

The aim of this work was to evaluate the prevalence of microalbuminuria in an obese population and to study the relation between albumin excretion rate (AER), various clinical (body mass index, adipose tissue distribution) nutritional (macronutrient intake) and metabolic parameters. A cross-sectional study was carried out, and AER was evaluated in182 obese subjects (BMI > 27) with no medication, no intercurrent disease, no cardiac, pulmonary or endocrinological disorders (including diabetes and hypertension) and also in 31 control subjects at the outpatient clinic of the department of Nutrition, Hotel Dieu, Paris, France. The following were measured: BMI, waist/hip ratio (WHR), urinary AER, blood glucose, insulin and C peptide levels, cholesterol (CT), triglycerides, HDL cholesterol (HDL-CT), apoprotein A, and B. In the obese population, 18 subjects (9.9%) were found to have an increased AER: 13subjects (7.1%) with microalbuminuria (AER between 30 to 300 mg/24 h)and five with AER over 300 mg/24 h. AER was normal in all control subjects but one, who was found to have microalbuminuria. Log AER was positively correlated to WHR (P < 0.001), blood pressure (P < 0.05), cholesterol (P < 0.05), Apo a levels (P < 0.01) and with fasting Insulin levels and protein intake (P < 0.001). Positive association between logAER and protein intake, insulin levels, Apo B and blood pressure werefound independently of BMI and WHR. It is suggested that abdominal obesity may be associated with incipient nephropathy in some obese subjects without diabetes and hypertension. Microalbuminuria may be included among metabolic abnormalities connected with abdominal-type excess weight distribution. Insulin resistance may be involved in the relationpreviously described between microalbuminuria and cardiovascular riskfactor and/or coronary heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:33:03