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Titolo:
ISOLATION OF HUMAN NUMA PROTEIN
Autore:
KEMPF T; BISCHOFF FR; KALIES I; PONSTINGL H;
Indirizzi:
GERMAN CANC RES CTR,DIV MOLEC BIOL MITOSIS,NEUENHEIMER FELD 280 D-69009 HEIDELBERG GERMANY GERMAN CANC RES CTR,DIV MOLEC BIOL MITOSIS D-69009 HEIDELBERG GERMANY UNIV ERLANGEN NURNBERG,INST & POLIKLIN KLIN IMMUNOL & RHEUMATOL D-91054 ERLANGEN GERMANY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 354, anno: 1994,
pagine: 307 - 310
SICI:
0014-5793(1994)354:3<307:IOHNP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOTIC APPARATUS PROTEIN; CHROMOSOME CONDENSATION; MONOCLONAL-ANTIBODY; NUCLEAR-PROTEIN; BINDING PROTEIN; DNA-REPLICATION; SPN ANTIGEN; PTK2 CELLS; SPINDLE; MITOSIS;
Keywords:
CHROMATIN CONDENSATION; CENTROSOME; RCC1; RAN; RANBP2; CELL CYCLE REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Kempf et al., "ISOLATION OF HUMAN NUMA PROTEIN", FEBS letters, 354(3), 1994, pp. 307-310

Abstract

NuMA is a protein involved in maintenance of nuclear structure and inthe assembly of the mitotic spindle. Expression of amino-terminal deletion mutants results in a phenotype identical to that caused by a temperature-sensitive defect of RCC1 (regulator of chromosome condensation). Here we describe the isolation of NuMA protein from HeLa cells under mild conditions as a prerequisite to study its interactions with elements of the RCC1-Ran regulatory pathway. In an overlay assay, NuMA did not bind Ran.[gamma-P-32]GTP. Thus it is clearly different from Ran. GTP binding proteins of similar M(1).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:47:29