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Titolo:
CORRELATION BETWEEN PLASMA-FIBRINOGEN AND SERUM-LIPIDS IN RATS WITH HYPERLIPIDEMIA INDUCED BY CHOLESTEROL FREE-HIGH FRUCTOSE OR HIGH CHOLESTEROL DIET
Autore:
OKAZAKI M; ZHANG H; YOSHIDA Y; ICHINO K; NAKAYAMA S; OGUCHI K;
Indirizzi:
SHOWA UNIV,SCH MED,DEPT PHARMACOL,SHINAGAWA KU TOKYO 142 JAPAN
Titolo Testata:
Journal of nutritional science and vitaminology
fascicolo: 5, volume: 40, anno: 1994,
pagine: 479 - 489
SICI:
0301-4800(1994)40:5<479:CBPASI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRINOLYTIC-ACTIVITIES; MYOCARDIAL-INFARCTION; ATHEROSCLEROSIS; MICE; ATHEROGENESIS; PATHOGENESIS; COAGULATION; VARIABLES; MODEL; CELLS;
Keywords:
FIBRINOGEN; CHOLESTEROL FREE-HIGH FRUCTOSE DIET; HIGH CHOLESTEROL DIET; HYPERLIPIDEMIA; COAGULATION; FIBRINOLYSIS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Okazaki et al., "CORRELATION BETWEEN PLASMA-FIBRINOGEN AND SERUM-LIPIDS IN RATS WITH HYPERLIPIDEMIA INDUCED BY CHOLESTEROL FREE-HIGH FRUCTOSE OR HIGH CHOLESTEROL DIET", Journal of nutritional science and vitaminology, 40(5), 1994, pp. 479-489

Abstract

We studied the coagulative and fibrinolytic activity in intrinsic or extrinsic hyperlipidemia using 4-week-old male Wistar rats. Intrinsic hyperlipidemia was induced by a cholesterol-free high-fructose diet (HFD) and extrinsic hyperlipidemia, by a high-cholesterol diet (HCD) for14 days. In intrinsic hyperlipidemic rats fed on the HFD, serum lipids were significantly increased as compared with the levels in control rats fed on a standard diet. An apparent increase in plasma fibrinogenlevel and coagulant factor XIII activity was also observed in HFD rats. In extrinsic hyperlipidemic rats fed on the HCD, significant increases in plasma fibrinogen level compared with that of control rats werefound with the increases in serum lipids. Activities of antithrombin III and alpha(2)-plasmin inhibitor in HFD-fed rats significantly increased compared with those of control and HFD rats. There was a significant positive correlation between plasma fibrinogen and serum total cholesterol, free cholesterol, or phospholipid in diet-induced hyperlipidemia (p < 0.01). Because of the increase in coagulant XIII activity inHFD-fed rats and the increase in alpha(2)-plasmin inhibitor activity in HCD-fed rats, both diet-induced hyperlipidemic rats were shown to have enhanced coagulative activity compared with the control rats. These results suggest that the HFD as well as the HCD causes a pre-hypercoagulative state due to the increase in plasma fibrinogen level and activities in other coagulative and fibrinolytic factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:14:50