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Titolo:
MODULATION OF AXON DIAMETER AND NEUROFILAMENTS BY HYPOMYELINATING SCHWANN-CELLS IN TRANSGENIC MICE
Autore:
COLE JS; MESSING A; TROJANOWSKI JQ; LEE VMY;
Indirizzi:
HOSP UNIV PENN,DEPT PATHOL & LAB MED,MALONEY BASEMENT ROOM A009 PHILADELPHIA PA 19104 UNIV PENN,SCH MED,DEPT PATHOL & LAB MED PHILADELPHIA PA 19104 UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI MADISON WI 53706
Titolo Testata:
The Journal of neuroscience
fascicolo: 11, volume: 14, anno: 1994,
parte:, 2
pagine: 6956 - 6966
SICI:
0270-6474(1994)14:11<6956:MOADAN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL DIABETIC NEUROPATHY; MYELIN-SPECIFIC PROTEINS; TREMBLER MOUSE; MAMMALIAN NEUROFILAMENTS; PHOSPHORYLATION SITES; NERVOUS-SYSTEM; SCIATIC-NERVE; MAJOR MYELIN; NF-H; EXPRESSION;
Keywords:
NEUROFILAMENTS; HYPOMYELINATION; TRANSGENIC MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Cole et al., "MODULATION OF AXON DIAMETER AND NEUROFILAMENTS BY HYPOMYELINATING SCHWANN-CELLS IN TRANSGENIC MICE", The Journal of neuroscience, 14(11), 1994, pp. 6956-6966

Abstract

Studies of peripheral nerves in two different lines of hypomyelinating transgenic mice support the hypothesis that myelinating Schwann cells exert a significant influence on key biological properties of axons. The mice contain transgenes combining the peripheral myelin protein zero gene (P-0) promoter and either the diphtheria toxin A chain gene product or the SV40 (simian virus 40) large T antigen. The consequencesof peripheral nerve hypomyelination on axon diameter, neurofilament (NF) density, and NF phosphorylation were analyzed. The sciatic nerves of the P-0 diphtheria toxin A transgenic mice (DT) evidenced the most severe hypomyelination, and this was associated with a dramatic decrease in NF phosphorylation plus a marked increase in NF density. In contrast, the sciatic nerves in the P-0 SV40 large T antigen transgenic mice (SV40) were not as severely hypomyelinated and there was a milder decrease in NF phosphorylation plus a more modest increase in NF density. Further, the sciatic nerves in both lines evidenced a decrease in axonal caliber without any change in NF content. Taken together, these studies provide strong evidence indicating that myelinating Schwann cells exert a significant influence on axon caliber by modulating NF phosphorylation and NF packing density in the axons of peripheral nerves. Thus, key biological properties of axons are modulated by signals transmitted from myelinating Schwann cells to axons of peripheral nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:25:09