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Titolo:
CORRELATED QUANTITATIVE STUDIES OF THE NEOSTRIATUM, NUCLEUS-ACCUMBENS, SUBSTANTIA-NIGRA, AND VENTRAL TEGMENTAL AREA IN NORMAL AND WEAVER MUTANT MICE
Autore:
BAYER SA; TRIARHOU LC; THOMAS JD; GHETTI B;
Indirizzi:
INDIANA UNIV PURDUE UNIV,DEPT BIOL,723 W MICHIGAN ST INDIANAPOLIS IN 46205 INDIANA UNIV PURDUE UNIV,DEPT PSYCHOL INDIANAPOLIS IN 46205 INDIANA UNIV,SCH MED,DEPT PATHOL & LAB MED INDIANAPOLIS IN 46202
Titolo Testata:
The Journal of neuroscience
fascicolo: 11, volume: 14, anno: 1994,
parte:, 2
pagine: 6901 - 6910
SICI:
0270-6474(1994)14:11<6901:CQSOTN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUB-CORTICAL AFFERENTS; HORSERADISH-PEROXIDASE; MOUSE WEAVER; POSTNATAL-DEVELOPMENT; FIBER VULNERABILITY; MESOSTRIATAL SYSTEM; DOPAMINE DEFICIENCY; CAUDATE-NUCLEUS; RAT; NEURONS;
Keywords:
STRIATUM; NUCLEUS ACCUMBENS; VENTRAL TEGMENTAL AREA; SUBSTANTIA NIGRA; WEAVER MUTANT MOUSE; CELL DEATH; VOLUMETRIC CELL COUNTS; 3-DIMENSIONAL COMPUTER RECONSTRUCTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Bayer et al., "CORRELATED QUANTITATIVE STUDIES OF THE NEOSTRIATUM, NUCLEUS-ACCUMBENS, SUBSTANTIA-NIGRA, AND VENTRAL TEGMENTAL AREA IN NORMAL AND WEAVER MUTANT MICE", The Journal of neuroscience, 14(11), 1994, pp. 6901-6910

Abstract

Normal mice (+/+)and homozygous weaver mutant mice (wv/wv) at 1 year of age were used for three-dimensional computer-aided reconstructions of the nucleus accumbens (NA) and neostriatum (ST) and for quantitative estimations of the total number of medium-sized neurons in the NA and ST, and for the total number of tyrosine hydroxylase (TH)-containingneurons in the ventral tegmental area (VTA) and substantia nigra (SN). The three-dimensional reconstructions showed that the weaver NA and ST are smaller than they are in +/+. Quantitative volumetric measurements of the NA and ST showed wv/wv were smaller than +/+ by nonsignificant differences of 14% and 13%, respectively. The wv/wv group showed statistically significant depletion of neurons in all four structures. On average, NA neurons are reduced by 27%, ST neurons by 22%, VTA-TH neurons by 40%, and SN-TH neurons by 79%. In wv/wv animals, there was ahigh positive correlation (r = 0.836) between the numbers of SN-TH neurons and ST neurons and a moderate positive correlation (r = 0.534) between the numbers of SN-VTA neurons and NA neurons. The nuclei in TH-containing neurons in wv/wv and +/+ had the same diameters, but in allanimals, the SN-TH neurons contained larger nuclei than the VTA-TH neurons. Cytoarchitectonic measurements in control and weaver NA and ST were also similar. In all animals, the NA contains more densely packedneurons with smaller nuclei than those in the ST.

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Documento generato il 01/12/20 alle ore 13:06:15