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Titolo:
PURIFIED RECONSTITUTED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS - THIOLREAGENTS ACT DIRECTLY ON RECEPTOR PROTEIN
Autore:
KAPLIN AI; FERRIS CD; VOGLMAIER SM; SNYDER SH;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI BALTIMORE MD 21205
Titolo Testata:
The Journal of biological chemistry
fascicolo: 46, volume: 269, anno: 1994,
pagine: 28972 - 28978
SICI:
0021-9258(1994)269:46<28972:PRI1R->2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CALCIUM-RELEASE; CA2+ RELEASE; TRISPHOSPHATE RECEPTOR; LIPID VESICLES; HAMSTER EGGS; BINDING-SITE; THIMEROSAL; OSCILLATIONS; CELLS; HEPATOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A.I. Kaplin et al., "PURIFIED RECONSTITUTED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS - THIOLREAGENTS ACT DIRECTLY ON RECEPTOR PROTEIN", The Journal of biological chemistry, 269(46), 1994, pp. 28972-28978

Abstract

Thimerosal, a sulfhydryl oxidizing reagent, has been shown to induce Ca2+ mobilization in several cell types and to increase the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate (IP3). Using purified IP3 receptor (IP(3)R) protein reconstituted in vesicles, we demonstrate pronounced stimulation by thimerosal of its Ca2+ channel activity. Effects of thimerosal are dependent on the redox state of the receptor, implying an action of thimerosal on a critical sulfhydryl group(s) of IP(3)R. Thimerosal enhances the affinity of IP(3)R forIP3 binding. The manner in which thimerosal modulates IP(3)R responsiveness to IP3 provides evidence for receptor heterogeneity with implications for mechanisms of quantal Ca2+ release. These results clarify regulation of IP(3)R activity by redox modulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 08:41:28