Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EVIDENCE THAT TOLERANCE TO THE ANXIOGENIC-LIKE EFFECTS OF MCPP DOES NOT INVOLVE ALTERATION IN THE FUNCTION OF 5-HT2C RECEPTORS IN THE RAT CHOROID-PLEXUS
Autore:
GRIEBEL G; MOREAU JL; JENCK F; MUTEL V; MARTIN JR; MISSLIN R;
Indirizzi:
UNIV HAWAII,BEKESY LAB NEUROBIOL,1993 EAST WEST RD HONOLULU HI 96822 F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA CH-4002 BASEL SWITZERLAND LAB PSYCHOPHYSIOL F-67000 STRASBOURG FRANCE
Titolo Testata:
Behavioural pharmacology
fascicolo: 6, volume: 5, anno: 1994,
pagine: 642 - 645
SICI:
0955-8810(1994)5:6<642:ETTTTA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; CHLOROPHENYLPIPERAZINE; ANTAGONISTS; ANXIETY; TFMPP;
Keywords:
ANXIETY; CHOROID PLEXUS; CHRONIC TREATMENT; ELEVATED PLUS-MAZE TEST; 5-HT2C RECEPTOR; LIGHT/DARK CHOICE PROCEDURE; MCPP; MOUSE; PHOSPHOINOSITIDE HYDROLYSIS; RAT;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
G. Griebel et al., "EVIDENCE THAT TOLERANCE TO THE ANXIOGENIC-LIKE EFFECTS OF MCPP DOES NOT INVOLVE ALTERATION IN THE FUNCTION OF 5-HT2C RECEPTORS IN THE RAT CHOROID-PLEXUS", Behavioural pharmacology, 5(6), 1994, pp. 642-645

Abstract

The mechanisms by which 1-(3-chlorophenyl) piperazine (mCPP) causes anxiety are unclear, but it has been suggested that the serotonin 5-HT2C receptor subtype may be involved in this effect. We have therefore studied the effect of chronic treatment (3 weeks) with mCPP in two animal models of anxiety (light/dark choice task in mice and elevated plus-maze test in rats) and subsequently assessed the function of 5-HT2C receptors (measured by maximal stimulation of 5-HT2C receptor-mediated phosphoinositide hydrolysis) in rat choroid plexus, where the receptoris present at very high levels, mCPP treatment regimens led to a tolerance to the anxiogenic-like action of the drug, but failed to alter the second messenger coupling of the 5-HT2C receptors in the choroid plexus, thereby suggesting the involvement of different mechanisms in this behavioral effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:00:54