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Titolo:
PROGRESS TOWARDS GENE-THERAPY FOR HIV-INFECTION
Autore:
YU M; POESCHLA E; WONGSTAAL F;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT MED,CLIN SCI BLDG,RM 410 SAN DIEGO CA 92093 UNIV CALIF SAN DIEGO,DEPT MED SAN DIEGO CA 92093 UNIV CALIF SAN DIEGO,DEPT BIOL SAN DIEGO CA 92093
Titolo Testata:
Gene therapy
fascicolo: 1, volume: 1, anno: 1994,
pagine: 13 - 26
SICI:
0969-7128(1994)1:1<13:PTGFH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HEMATOPOIETIC STEM-CELLS; HUMAN T-CELLS; BONE-MARROW TRANSPLANTATION; RECOMBINANT SOLUBLE CD4; BLOOD PROGENITOR CELLS; REV TRANS-ACTIVATOR; WILD-TYPE VIRUS; ANTI-SENSE RNA; ANTISENSE RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
158
Recensione:
Indirizzi per estratti:
Citazione:
M. Yu et al., "PROGRESS TOWARDS GENE-THERAPY FOR HIV-INFECTION", Gene therapy, 1(1), 1994, pp. 13-26

Abstract

The retroviral life cycle and genetic plasticity of human immunodeficiency virus 1 (HIV-1) present unprecedented therapeutic challenges. Twelve years into the HIV epidemic, satisfactory treatment remains elusive. Our current understanding of AIDS pathogenesis calls for early intervention with antiviral agents. Although still in its infancy, human gene therapy holds considerable potential for the long term treatment of genetic disorders, cancer and chronic infectious diseases. Gene therapy for HIV infection is receiving particularly intensive study: approaches that are in development include both immunotherapy (e.g. therapeutic vaccines and adoptive transfer of CD8(+) T-cell clones) and direct antiviral therapy (intracellular immunization). The latter strategies include transdominant modifications of HIV proteins, RNA decoys, antisense RNA, ribozymes and modifications of cellular proteins (e.g. intracellular antibodies, soluble CD4). Several of these strategies are now entering clinical trials. While significant conceptual and technical hurdles remain to be overcome before the promise of gene therapy for HIV infection can be fully realized, progress in this field is likely to be rapid and to contribute to the border applicability of human gene therapy to the treatment of other disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:08:21