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Titolo:
IMMUNE RESPONSIVENESS AND LYMPHOKINE PRODUCTION IN PATIENTS WITH TUBERCULOSIS AND WEALTHY CONTROLS
Autore:
SANCHEZ FO; RODRIGUEZ JI; AGUDELO G; GARCIA LF;
Indirizzi:
UNIV ANTIOQUIA,FAC MED,CENT INVEST LAB MEDELLIN 1226A COLOMBIA UNIV ANTIOQUIA,FAC MED,CENT INVEST LAB MEDELLIN 1226A COLOMBIA UNIV ANTIOQUIA,FAC CIENCIAS EXACTAS & NAT,DEPT MATEMAT MEDELLIN 1226ACOLOMBIA
Titolo Testata:
Infection and immunity
fascicolo: 12, volume: 62, anno: 1994,
pagine: 5673 - 5678
SICI:
0019-9567(1994)62:12<5673:IRALPI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE PULMONARY TUBERCULOSIS; GAMMA-INTERFERON PRODUCTION; MYCOBACTERIUM-TUBERCULOSIS; ANTIGEN-SPECIFICITY; CYTOKINE PATTERNS; LYMPHOCYTES-T; MESSENGER-RNA; TH2 CLONES; CELLS; DELTA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
F.O. Sanchez et al., "IMMUNE RESPONSIVENESS AND LYMPHOKINE PRODUCTION IN PATIENTS WITH TUBERCULOSIS AND WEALTHY CONTROLS", Infection and immunity, 62(12), 1994, pp. 5673-5678

Abstract

The aim of the present study was to determine the profile of immune responsiveness that differentiates patients with tuberculosis (TB) fromhealthy tuberculin-positive controls. Forty-five patients with pulmonary TB and 16 healthy tuberculin-positive controls, all human immunodeficiency virus negative, were studied, Patients had decreased reactivity to tuberculin, diminished proliferative response to purified protein derivative (PPD), lower concentrations of interleukin-2 (II-2) and gamma interferon in PPD-stimulated cultures, no increase in the percentage of gamma/delta cells in PPD-stimulated cultures, and higher immunoglobulin G antimycobacterial antibodies compared with control subjects. Furthermore, controls exhibited decreased production of IL-4 by PPI-stimulated cells. Multivariate discriminant and factor analyses demonstrated divergent patterns of immune reactivity against mycobacterial antigens. The association of IL-4 and immunoglobulin G antibody levels in patients, in contrast to the high reactivity to tuberculin, increased proliferation to PPD, and higher levels of IL-2 and gamma interferon observed in healthy controls suggested that most TB patients exhibita TH2 pattern of immune responsiveness while tuberculin-positive healthy individuals have a TH1 pattern.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:08:56