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Titolo:
THE EFFICACY OF (L)-2-OXOTHIAZOLIDINE-4-CARBOXYLATE (OTC) AND (L)-CYSTEINE IN REDUCING URINARY OXALATE EXCRETION
Autore:
BAKER PW; BAIS R; ROFE AM;
Indirizzi:
INST MED & VET SCI,DIV CLIN BIOCHEM,FROME RD ADELAIDE SA 5000 AUSTRALIA INST MED & VET SCI,DIV CLIN BIOCHEM ADELAIDE SA 5000 AUSTRALIA
Titolo Testata:
The Journal of urology
fascicolo: 6, volume: 152, anno: 1994,
parte:, 1
pagine: 2139 - 2146
SICI:
0022-5347(1994)152:6<2139:TEO((A>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASOLATERAL MEMBRANE-VESICLES; LACTATE-DEHYDROGENASE; INORGANIC SULFATE; RAT-KIDNEY; CYSTEINE; TRANSPORT; CALCIUM; METABOLISM; INHIBITION; GLYOXYLATE;
Keywords:
CYSTEINE; CALCIUM OXALATE; KIDNEY CALCULI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P.W. Baker et al., "THE EFFICACY OF (L)-2-OXOTHIAZOLIDINE-4-CARBOXYLATE (OTC) AND (L)-CYSTEINE IN REDUCING URINARY OXALATE EXCRETION", The Journal of urology, 152(6), 1994, pp. 2139-2146

Abstract

The effects of orally administered (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylate (OTC) on urinary oxalate excretion were investigated in male Porton rats, as (L)-cysteine has been shown to form an adduct with glyoxylate in vitro. Feeding of OTC (204 +/- 1 mg.per day) for 5 days increased urinary cyst(e)ine, p < 0.001; sulphate, p < 0.001; phosphate, p < 0.05; and calcium, p < 0.05; and decreased urinary pH, p< 0.001. In addition, OTC feeding significantly decreased urinary oxalate excretion when compared with controls, p < 0.05 (Delta OTC-Delta Control -4.26 +/- 1.55 nmol./day/gm.). In the 5-day period after cessation of OTC feeding, all urinary parameters returned to control levels. At the completion of this recovery period there were no significant differences in any of the clinically significant plasma parameters. When fed for 22 days (191 +/- 3 mg. per day) OTC decreased urinary oxalate compared with controls, p < 0.05 (Delta OTC-Delta Control -9.47 +/-4.24 nmol./day/gm.). Other urinary parameters (uric acid, magnesium, calcium, phosphate, creatinine, pH and volume) were not significantly altered by OTC feeding. Again, at the completion of this feeding period there were no significant differences in any of the clinically significant plasma parameters. (L)-cysteine feeding for 5 days (184 +/- 10 mg. per day) increased urinary sulphate, p < 0.001; and magnesium, p <0.05, and decreased urinary pH, p < 0.001. In addition, (L)-cysteine feeding did not significantly change urinary oxalate excretion when compared with the controls (Delta(L)-Cysteine-Delta Control -2.94 +/- 2.14 nmol./day/gm.). However, at the completion of this feeding period, plasma urate, p < 0.02; and glucose, p < 0.05, were decreased, and plasma potassium, p < 0.01, was increased. These results indicate that orally administered OTC is effective in reducing urinary oxalate excretion without altering plasma biochemistry. It is suggested that (L)-cysteine-glyoxylate adduct formation is the mechanism by which OTC reducesurinary oxalate excretion through a reduction in endogenous oxalate production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:18:04