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Titolo:
INTERLEUKIN-8 AND NEUTROPHILS IN SYSTEMIC-SCLEROSIS WITH LUNG INVOLVEMENT
Autore:
CRESTANI B; SETA N; PALAZZO E; ROLLAND C; VENEMBRE P; DEHOUX M; BOUTTEN A; SOLER P; DOMBRET MC; KAHN MF; AUBIER M;
Indirizzi:
HOP BICHAT,INSERM,U408,U82,SERV PNEUMOL,SERV RHUMATOL,UNITE PNEUMOL,46 RUE HENRI HUCHARD F-75018 PARIS FRANCE HOP BICHAT,INSERM,U408,U82,SERV PNEUMOL,SERV RHUMATOL,UNITE PNEUMOL F-75018 PARIS FRANCE HOP BICHAT,BIOCHIM LAB A F-75877 PARIS FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 5, volume: 150, anno: 1994,
pagine: 1363 - 1367
SICI:
1073-449X(1994)150:5<1363:IANISW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PULMONARY FIBROSIS; LOWER RESPIRATORY-TRACT; COLLAGEN-VASCULAR DISEASES; ALVEOLAR MACROPHAGES; GENE-EXPRESSION; ALPHA-1-PROTEINASE INHIBITOR; BRONCHOALVEOLAR LAVAGE; CHRONIC INFLAMMATION; ENDOTHELIAL-CELLS; CYSTIC-FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
B. Crestani et al., "INTERLEUKIN-8 AND NEUTROPHILS IN SYSTEMIC-SCLEROSIS WITH LUNG INVOLVEMENT", American journal of respiratory and critical care medicine, 150(5), 1994, pp. 1363-1367

Abstract

We investigated the mechanisms and consequences of neutrophil accumulation in the airspace in 11 patients with systemic sclerosis (SSc) andinterstitial lung disease. Seven normal subjects served as controls. We measured total neutrophil elastase burden, elastase activity, and alpha-1-antitrypsin (alpha1AT) in bronchoalveolar lavage (BAL) fluid and we evaluated the in vitro interleukin-8 (IL-8, a potent chemoattractant for neutrophils) secretion by alveolar macrophages (AM). A mild neutrophil alveolitis was observed in patients when compared with control subjects. Total BAL elastase burden was higher in patients than in control subjects and correlated positively with the percentage of neutrophils in BAL. BAL elastase activity was undetectable in control subjects, but it was detected in all patients but one (mean:257 +/- 87 mU/L). Spontaneous IL-8 secretion by AM was higher in patients with SSc than in control subjects (518 +/- 115 versus 228 +/- 65 ng/ml, p = 0.04) and positively correlated with the percentage of neutrophils in BAL (r = 0.505). We conclude that (1) the neutrophil could participate in the pathogenesis of SSc lung disease through the release of elastase; (2) the AM could contribute to the influx of neutrophils in the alveolus through the release of IL-8.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:04:48