Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE ORGANIZATION OF THE HUMAN-COMPLEMENT FACTOR-I GENE (IF) - A MEMBER OF THE SERINE-PROTEASE GENE FAMILY
Autore:
VYSE TJ; BATES GP; WALPORT MJ; MORLEY BJ;
Indirizzi:
HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED,RHEUMATOL UNIT,DU CANE RD LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED,RHEUMATOL UNIT LONDON W12 0NN ENGLAND UNITED MED & DENT SCH,GUYS HOSP,DIV MED & MOLEC GENET LONDON SE1 9RT ENGLAND
Titolo Testata:
Genomics
fascicolo: 1, volume: 24, anno: 1994,
pagine: 90 - 98
SICI:
0888-7543(1994)24:1<90:TOOTHF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROFIBROMATOSIS TYPE-1 GENE; C3B INACTIVATOR; CELL-SURFACE; DNA; PROTEINS; INTRON; SEQUENCES; FRAGMENTS; COFACTOR; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Vyse et al., "THE ORGANIZATION OF THE HUMAN-COMPLEMENT FACTOR-I GENE (IF) - A MEMBER OF THE SERINE-PROTEASE GENE FAMILY", Genomics, 24(1), 1994, pp. 90-98

Abstract

The human complement factor I gene (IF) was cloned from a how-sorted cosmid library. The gene spans 63 kb and comprises 13 exons. The firstexon, which encodes the leader sequence and 5' untranslated region, is separated from the body of the gene by a large intron of 36 kb. Factor I is a mosaic protein, and there is a correlation between the genomic organization and the modular structure of the protein. The second exon encodes a module found only in complement C6 and C7 (FI/C6/C7); the third and fourth exons encode a single CD5 domain; and the fifth andsixth exons each encode a low-density Lipoprotein receptor module. Two very small exons, 21 and 36 bp, then separate the first six exons from the last five that encode the serine protease domain of factor I. Within the serine protease gene family factor I has a unique genomic structure, but it bears a much closer resemblance to trypsin than it does to the other complement system serine proteases, factor B, C2, and C1r/C1s. (C) 1994 Academic Press,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 00:45:13