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Titolo:
INTERACTION BETWEEN SAM68 AND SRC FAMILY TYROSINE KINASES, FYN AND LCK, IN T-CELL RECEPTOR SIGNALING
Autore:
FUSAKI N; IWAMATSU A; IWASHIMA M; FUJISAWA J;
Indirizzi:
KANSAI MED UNIV,DEPT MICROBIOL,10-15 FUMIZONO CHO MORIGUCHI OSAKA 570JAPAN KANSAI MED UNIV,DEPT MICROBIOL MORIGUCHI OSAKA 570 JAPAN KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL,KANAZAWA KU YOKOHAMA KANAGAWA 236 JAPAN MITSUBISHI KASEI INST LIFE SCI,DIV CELL & INFORMAT PRECURSORY RES EMBRYON SCI,RES DEV CORP JAPAN MACHIDA TOKYO 194 JAPAN
Titolo Testata:
The Journal of biological chemistry
fascicolo: 10, volume: 272, anno: 1997,
pagine: 6214 - 6219
SICI:
0021-9258(1997)272:10<6214:IBSASF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-CBL PROTOONCOGENE; JAK-3 JANUS KINASE; ANTIGEN RECEPTOR; SH3 DOMAINS; HTLV-I; PHOSPHATIDYLINOSITOL 3-KINASE; HEMATOPOIETIC-CELLS; BINDING-PROTEIN; NUCLEIC-ACID; PROLINE-RICH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
N. Fusaki et al., "INTERACTION BETWEEN SAM68 AND SRC FAMILY TYROSINE KINASES, FYN AND LCK, IN T-CELL RECEPTOR SIGNALING", The Journal of biological chemistry, 272(10), 1997, pp. 6214-6219

Abstract

The Src family protein-tyrosine kinase, Fyn, is associated with the Tcell receptor (TCR) and plays an important role in TCR-mediated signaling. We found that a human T cell leukemia virus type 1-infected T cell line, Hayai, overexpressed Fyn. To identify the molecules downstream of Fyn, we analyzed the tyrosine phosphorylation of cellular proteins in the cells. In Hayai, a 68-kDa protein was constitutively tyrosine-phosphorylated. The 68-kDa protein was coimmunoprecipitated with various signaling proteins such as phospholipase C gamma 1, the phosphatidylinositol 3-kinase p85 subunit, Grb(2), SHP-1, Cb1, and Jak3, implying that the protein might function as an adapter. Purification and microsequencing of this protein revealed that it was the RNA-binding protein, Sam68 (Src associated in mitosis, 68 kDa). Sam68 was associated with the Src homology 2 and 3 domains of Fyn and also those of another Src family kinase, Lck. CD3 cross linking induced tyrosine phosphorylation of Sam68 in uninfected T cells. These data suggest that Sam68 participates in the signal transduction pathway downstream of TCR-coupled Src family kinases Fyn and Lck in lymphocytes, that is not only in themitotic pathway downstream of c-Src in fibroblasts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:25:12