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Titolo:
ROLE OF NITRIC-OXIDE IN REGULATION OF BARORECEPTOR REFLEX
Autore:
JIMBO M; SUZUKI H; ICHIKAWA M; KUMAGAI K; NISHIZAWA M; SARUTA T;
Indirizzi:
KEIO UNIV,SCH MED,DEPT INTERNAL MED,SHINJUKU KU,35 SHINANOMACHI TOKYOJAPAN KEIO UNIV,SCH MED,DEPT INTERNAL MED,SHINJUKU KU TOKYO JAPAN
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 2, volume: 50, anno: 1994,
pagine: 209 - 219
SICI:
0165-1838(1994)50:2<209:RONIRO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; L-ARGININE; CONSCIOUS RABBITS; RELAXING FACTOR; BLOOD-PRESSURE; RELEASE; BAROREFLEX; SYSTEM; HEMODYNAMICS; HYPERTENSION;
Keywords:
NITRIC OXIDE; BARORECEPTOR REFLEX; RENAL SYMPATHETIC NERVE ACTIVITY; AORTIC NERVE ACTIVITY; CERVICAL SYMPATHETIC NERVE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Jimbo et al., "ROLE OF NITRIC-OXIDE IN REGULATION OF BARORECEPTOR REFLEX", Journal of the autonomic nervous system, 50(2), 1994, pp. 209-219

Abstract

The possible role of nitric oxide (NO) on modulating sympathetic nerve activity through its action on baroreceptor reflex are was investigated. L-Arginine, a precursor of NO, and N-G-monomethyl-L-arginine (L-NMMA), an inhibitor of NO synthase, were separately infused intravenously in increasing doses in 126 pentobarbital-anesthetized rabbits. Meanarterial pressure (MAP), heart rate (HR), aortic nerve activity (ANA), cervical (CSNA) and renal sympathetic nerve activities (RSNA) were recorded. L-Arginine infusion decreased MAP (P < 0.05), ANA (P < 0.05),CSNA (P < 0.05) and RSNA (P < 0.05) without changes in HR. Infusion of D-arginine, an enantiomer of L-arginine, and simultaneous infusion of L-arginine and L-NMMA, did not elicit such changes. L-NMMA infusion increased MAP (P < 0.05) and ANA (P < 0.05) and decreased HR (P < 0.05), while it tended to increase CSNA and RSNA without significance. Infusion of L-arginine or L-NMMA did not alter the slope of ANA, CSNA, RSNA, or HR in relation to MAP, These results suggest that NO modulates efferent sympathetic nerve activity, not by altering the afferent or efferent limbs of the baroreceptor reflex are, but by interacting with the sympathetic pathway in the central nervous system.

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Documento generato il 29/11/20 alle ore 15:40:32