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Titolo:
BIMODAL EFFECT OF PLATELET-ACTIVATING-FACTOR (PAF) ON AIRWAYS RESPONSIVENESS IS THE RABBIT
Autore:
NIEMINEN MM; HENSON PM; IRVIN CG;
Indirizzi:
TAMPERE UNIV HOSP,DEPT PULM MED SF-36280 PIKONLINNA FINLAND NATL JEWISH CTR IMMUNOL & RESP MED,PULM PHYSIOL UNIT DENVER CO 80206 UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV PULM SERV DENVER CO 80262
Titolo Testata:
Experimental lung research
fascicolo: 6, volume: 20, anno: 1994,
pagine: 559 - 577
SICI:
0190-2148(1994)20:6<559:BEOP(O>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCERYL ETHER PHOSPHORYLCHOLINE; INDUCED BRONCHOCONSTRICTION; ALVEOLAR MACROPHAGES; HUMAN EOSINOPHILS; GUINEA-PIG; INFLAMMATION; METABOLISM; ASTHMA; LUNG; RAT;
Keywords:
PLATELET-ACTIVATING FACTOR; AIRWAYS RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Nieminen et al., "BIMODAL EFFECT OF PLATELET-ACTIVATING-FACTOR (PAF) ON AIRWAYS RESPONSIVENESS IS THE RABBIT", Experimental lung research, 20(6), 1994, pp. 559-577

Abstract

The role of platelet-activating factor (PAF) to increase airways responsiveness is unclear. Since PAF has unusual dose-response characteristics in vitro, this study investigated the effects of different doses or concentrations of PAF given by intravenous and aerosol administration in anesthetized rabbits. Aerosol PAF caused a dose-dependent decrease in SG(L). Intravenous administration of PAF was associated with thrombocytopenia and neutropenia, whereas aerosol administration of PAF did not alter the numbers of circulatory cells. With either administration, no inflammatory cells were recovered by lavage nor was there evidence of a gross inflammatory process within the lung. Furthermore, there was no evidence of a late asthmatic response. Intravenous PAF caused a bimodal change ill airways responsiveness with a significant increase in the effective concentration causing 50% of the maximal change in SG(L) (EC(50)SG(L)) at low doses (0.06-06 mu g/kg h(-1)) and a significant decrease in EC(50)SG(L) (an increase in responsiveness) at higher doses (1.2-2.4 mu g/kg/h(-1)). Aerosol PAF decreased EC(50)SG(L) significantly at the higher doses (100-250 mu g). These changes in EC(50)SG(L), after both administrations, were still apparent at 31/2 and 4 h. In conclusion PAF has a dose-dependent, biphasic, and persistent effect on airways responsiveness, which may be independent of circulating inflammatory cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:00:44