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Titolo:
PASSIVE-AVOIDANCE LEARNING INDUCED CHANGE IN GAP43 PHOSPHORYLATION INDAY-OLD CHICKS
Autore:
ZHAO WQ; NG KT; SEDMAN GL;
Indirizzi:
LA TROBE UNIV,DEPT PSYCHOL BUNDOORA VIC 3083 AUSTRALIA LA TROBE UNIV,DEPT PSYCHOL BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Brain research bulletin
fascicolo: 1, volume: 36, anno: 1995,
pagine: 11 - 17
SICI:
0361-9230(1995)36:1<11:PLICIG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; LONG-TERM POTENTIATION; B-50 GAP-43; NEUROTRANSMITTER RELEASE; NORADRENALINE RELEASE; SIGNAL TRANSDUCTION; SYNAPTIC PLASTICITY; SELECTIVE INCREASE; MEMORY FORMATION; K+ CURRENTS;
Keywords:
INTERMEDIATE MEMORY; MEMORY CONSOLIDATION; LONG-TERM MEMORY; DAY-OLD CHICKS; DISCRIMINATION LEARNING; PROTEIN-PHOSPHORYLATION; GAP43; TOTAL KINASE ACTIVITY; PROTEIN KINASE C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
W.Q. Zhao et al., "PASSIVE-AVOIDANCE LEARNING INDUCED CHANGE IN GAP43 PHOSPHORYLATION INDAY-OLD CHICKS", Brain research bulletin, 36(1), 1995, pp. 11-17

Abstract

Day-old chicks trained on a single trial passive discriminated avoidance task demonstrated a significant increase in in vitro phosphorylation of a 50 kDa protein in P2M fractions of total forebrain. The increase occurred 30 min posttraining, at a time when previous reports suggest that mechanisms for triggering protein synthesis-dependent long-term memory consolidation are activated. These changes in phosphorylationrates were accompanied by a substantial enhancement of total kinase activity. Immunoblotting studies with monoclonal anti-GAP43 antibody indicate that this protein is GAP43. These results contradict previous reports of a decrease in in vitro GAP43 phosphorylation following the same learning paradigm. A number of procedural differences may account for this discrepancy. The results suggest that changes in the phosphorylation state may be associated with mechanisms triggering long-term memory consolidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:09:24