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Titolo:
GENETIC-ANALYSIS OF ATOPY AND ASTHMA AS QUANTITATIVE TRAITS AND ORDERED POLYCHOTOMIES
Autore:
LAWRENCE S; BEASLEY R; DOULL I; BEGISHVILI B; LAMPE F; HOLGATE ST; MORTON NE;
Indirizzi:
UNIV SOUTHAMPTON,PRINCESS ANNE HOSP,CTR HUMAN GENET,LEVEL G SOUTHAMPTON SO9 4HA HANTS ENGLAND WELLINGTON SCH MED,DEPT PULM MED WELLINGTON NEW ZEALAND UNIV SOUTHAMPTON,GEN HOSP SOUTHAMPTON SO9 4XY HANTS ENGLAND
Titolo Testata:
Annals of Human Genetics
, volume: 58, anno: 1994,
parte:, 4
pagine: 359 - 368
SICI:
0003-4800(1994)58:<359:GOAAAA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE; RESPONSIVENESS; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S. Lawrence et al., "GENETIC-ANALYSIS OF ATOPY AND ASTHMA AS QUANTITATIVE TRAITS AND ORDERED POLYCHOTOMIES", Annals of Human Genetics, 58, 1994, pp. 359-368

Abstract

Traits related to atopy and asthma were defined in a random cohort of131 families with three or more children. Correlation analysis provides no evidence of imprinting, maternal effect, or a major role of environment shared by sibs. Commingling analysis favours more than one distribution, the upper one being common for asthma and very common for atopy. Segregation analysis of rank-transformed variables provides onlyequivocal evidence of major genes against a polygenic background but suggests that such genes (if present) are individually common and not of large effect. Segregation analysis under a two-locus model gives consistent results with minimal distributional assumptions. To enter combined segregation analysis we favour a restricted model in which the major locus is additive on the liability scale and the pseudopolygenic modifier locus accounts for at least half the genetic variance. Total IgE and bronchial reactivity are proposed for meta-analysis of atopy and asthma respectively. Genetic analysis of complex inheritance is discussed and it is shown that allelic association with random loci is not a feasible approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 03:52:02