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Titolo:
BINDING AND CAMP STUDIES OF MELANOTROPIN PEPTIDES WITH THE CLONED HUMAN PERIPHERAL MELANOCORTIN RECEPTOR, HMC1R
Autore:
HASKELLLUEVANO C; MIWA H; DICKINSON C; HRUBY VJ; YAMADA T; GANTZ I;
Indirizzi:
UNIV ARIZONA,DEPT CHEM TUCSON AZ 85721 UNIV ARIZONA,DEPT CHEM TUCSON AZ 85721 UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT PEDIAT ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT PHYSIOL ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT SURG ANN ARBOR MI 48109
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 3, volume: 204, anno: 1994,
pagine: 1137 - 1142
SICI:
0006-291X(1994)204:3<1137:BACSOM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE BIOLOGICAL-ACTIVITIES; MELANOCYTE-STIMULATING HORMONE; POTENT SYNTHETIC MELANOTROPIN; ACTIVE-SITE ANALOGS; ALPHA-MELANOTROPIN; SKIN; CLONING; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C. Haskellluevano et al., "BINDING AND CAMP STUDIES OF MELANOTROPIN PEPTIDES WITH THE CLONED HUMAN PERIPHERAL MELANOCORTIN RECEPTOR, HMC1R", Biochemical and biophysical research communications, 204(3), 1994, pp. 1137-1142

Abstract

Binding and stimulation of cAMP by the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone) and its superpotent analogues[Nle(4), ($) under bar DPhe(7)] alpha-MSH (MT-I) and [GRAPHICS] alpha-MSH(4-10)-NH2 (MT-II) were undertaken to examine their respective properties on the human peripheral melanocyte melanocortin receptor, hMC1R. alpha-MSH was found to possess a binding IC50 value of 6.5 +/- 0.9 x 10(-9) M and cAMP EC(50) value of 2.0 +/- 0.6 x 10(-9) M. MT-I possesses a binding IC50 value of 1.2 +/- 0.3 x 10(-9) M and a cAMP EC(50) of 0.5 +/- 0.03 x 10(-9) M. MT-II possesses a binding IC50 of 0.57 +/-0.08 x 10(-9) M and cAMP EC(50) value of 0.20 +/- 0.05 X 10(-9) M. (C) 1994 Academic Press. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:17:36