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Titolo:
EFFECTS OF COMPETITIVE AND NONCOMPETITIVE N-METHYL-D-ASPARTATE (NMDA)ANTAGONISTS IN SQUIRREL-MONKEYS TRAINED TO DISCRIMINATE D-CPPENE (SDZ-EAA-494) FROM VEHICLE
Autore:
WILEY JL; BALSTER RL;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 116, anno: 1994,
pagine: 266 - 272
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; RECEPTOR ANTAGONISTS; STIMULUS PROPERTIES; PHENCYCLIDINE-LIKE; PHARMACOLOGICAL SPECIFICITY; RECOGNITION SITES; RHESUS-MONKEYS; RATS; SALINE; MK-801;
Keywords:
CPPENE; SDZ EAA 494; NMDA ANTAGONISTS; DRUG DISCRIMINATION; MONKEYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Wiley e R.L. Balster, "EFFECTS OF COMPETITIVE AND NONCOMPETITIVE N-METHYL-D-ASPARTATE (NMDA)ANTAGONISTS IN SQUIRREL-MONKEYS TRAINED TO DISCRIMINATE D-CPPENE (SDZ-EAA-494) FROM VEHICLE", Psychopharmacology, 116(3), 1994, pp. 266-272

Abstract

Drug discrimination studies have proven useful for comparing and contrasting the behavioral effects of site-selective N-methyl-D-aspartate (NMDA) antagonists. This study examined the effects of competitive andnon-competitive NMDA antagonists in squirrel monkeys trained to discriminate 1 mg/kg D-CPPene (2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid; SDZ EAA 494] from vehicle in a two-lever drug discrimination procedure. Results show that D-CPPene and several other competitiveNMDA antagonists (NPC 17742, CGS 19755, and CGP 37849) completely substituted for D-CPPene in a dose-dependent manner. In contrast, phencyclidine (PCP) and ketamine produced only partial substitution at doses that severely suppressed response rates. These results are consistent with results of earlier studies with rats and monkeys showing differences in the discriminative stimulus effects of competitive and PCP-likenon-competitive NMDA antagonists. The data support the predictions (1) that D-CPPene and the other competitive NMDA antagonists tested would have similar subjective effects in humans and (2) that some differences would be found in the subjective effects of competitive NMDA antagonists and PCP-like non-competitive antagonists.

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Documento generato il 30/11/20 alle ore 03:14:20