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Titolo:
BLOCK OF STRETCH-ACTIVATED ATRIAL-NATRIURETIC-PEPTIDE SECRETION BY GADOLINIUM IN ISOLATED RAT ATRIUM
Autore:
LAINE M; ARJAMAA O; VUOLTEENAHO O; RUSKOAHO H; WECKSTROM M;
Indirizzi:
UNIV OULU,BIOCTR OULU,KAJAANINTIE 52A SF-90220 OULU FINLAND UNIV OULU,DEPT PHARMACOL & TOXICOL SF-90220 OULU FINLAND
Titolo Testata:
Journal of physiology
, volume: 480, anno: 1994,
parte:, 3
pagine: 553 - 561
SICI:
0022-3751(1994)480:<553:BOSASB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED CHICK HEART; ION CHANNELS; CALCIUM CHANNELS; MECHANICAL STRETCH; ENDOTHELIAL-CELLS; RELEASE; TRANSDUCTION; MYOCYTES; INVOLVEMENT; PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Laine et al., "BLOCK OF STRETCH-ACTIVATED ATRIAL-NATRIURETIC-PEPTIDE SECRETION BY GADOLINIUM IN ISOLATED RAT ATRIUM", Journal of physiology, 480, 1994, pp. 553-561

Abstract

1. Isolated superfused rat atrial preparations were used to study themechanism of stretch-induced atrial natriuretic peptide (ANP) secretion. The stretch of the atrial myocytes was induced by raising the intra-atrial pressure. The secretion rates were analysed by measuring ANP concentrations from the superfusate fractions by radioimmunoassay. 2. The effect of gadolinium, a blocker of stretch-activated ion channels,on stretch-induced and basal ANP secretion was investigated by superfusing the atrial preparation with 5, 20 or 80 mu M GdCl3. Gadolinium decreased stretch-induced ANP secretion in a dose-dependent manner, butdid not affect basal secretion. 3. Because high concentrations of gadolinium may block voltage-gated calcium channels, we tested whether the selective blockers of L-type (diltiazem) and T-type (NiCl2) calcium channels affect the stretch-stimulated ANP release. Neither diltiazem at 3 mu M nor NiCl2 at 50 mu M affected stretch-induced ANP release inpaced atrial preparation. 4. Gadolinium, but not diltiazem, also inhibited stretch-stimulated ANP secretion in non-paced, quiescent atria. 5. The findings that ANP release is inhibited by Gd3+, but not by diltiazem or NiCl2, and that the stretch-induced secretion in quiescent atria is also inhibited by Gd3+, suggest that stretch-activated ion channels are involved in the regulation of stretch-induced ANP release.

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Documento generato il 05/12/20 alle ore 01:29:11