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Titolo:
THE HEMATOPOIETIC STEM-CELL TRANSPLANTATION IN HODGKINS-DISEASE - QUESTIONS AND CONTROVERSIES
Autore:
FLEURY J; LEGROS M; CURE H; TORTOCHAUX J; CONDAT P; DIONET C; TRAVADE P; BELEMBAOGO E; TAVERNIER F; KWIATKOWSKI F; CHOLLET P; PLAGNE R;
Indirizzi:
CTR JEAN PERRIN,UNITE TRANSPLANTAT MEDULLAIRE,58 RUE MONTALEMBERT,BP 392 F-63011 CLERMONT FERRAND FRANCE
Titolo Testata:
Leukemia & lymphoma
fascicolo: 5-6, volume: 15, anno: 1994,
pagine: 419 - 432
SICI:
1042-8194(1994)15:5-6<419:THSTIH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Keywords:
HODGKINS DISEASE; HEMATOPOIETIC STEM CELL; TRANSPLANTATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J. Fleury et al., "THE HEMATOPOIETIC STEM-CELL TRANSPLANTATION IN HODGKINS-DISEASE - QUESTIONS AND CONTROVERSIES", Leukemia & lymphoma, 15(5-6), 1994, pp. 419-432

Abstract

Most patients with Hodgkin's disease (HD) are cured with chemotherapyand/or radiotherapy. However, half of those with advanced stage disease (IIIB, IV) do not respond adequately to treatment or relapse. Salvage therapy used in such cases gives from 10% to 50% complete remissionbut only 10% long term survival. The results of bone marrow transplantation reported in acute leukemia and non-Hodgkin's lymphoma encouraged some authors to develop this new therapeutic strategy in Hodgkin's disease. In the early 1980's promising results were achieved when refractory and relapsed patients were selected to receive myeloablative therapy followed by bone marrow transplantation. Today, high dose chemotherapy with hematopoietic stem cell transplantation (HSCT) is used moreand more often in poor prognosis Hodgkin's disease. After a review ofthe literature concerning the results of transplantation in Hodgkin'sdisease, we develop the numerous problems associated with this procedure which remain to be solved such as: the optimal indication, the timing of HSCT, the type of graft, the conditioning regimen, the place ofradiotherapy and the optimal use of hematopoietic growth factors. We conclude with future prospects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:42:03