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Titolo:
CYTOTOXIC ACTIVITY AGAINST MAEDI-VISNA VIRUS-INFECTED MACROPHAGES
Autore:
LEE WC; MCCONNELL I; BLACKLAWS BA;
Indirizzi:
UNIV EDINBURGH,DEPT VET PATHOL EDINBURGH EH9 1QH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT VET PATHOL EDINBURGH EH9 1QH MIDLOTHIAN SCOTLAND
Titolo Testata:
Journal of virology
fascicolo: 12, volume: 68, anno: 1994,
pagine: 8331 - 8338
SICI:
0022-538X(1994)68:12<8331:CAAMVM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXIC LYMPHOCYTES-T; LENTIVIRUS-INDUCED ARTHRITIS; ACTIVATED KILLER-CELLS; PHENOTYPIC ANALYSIS; SEROPOSITIVE INDIVIDUALS; MONOCLONAL-ANTIBODIES; PERIPHERAL-BLOOD; LYMPHOID-TISSUE; HUMAN-MONOCYTES; SYNOVIAL-FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
W.C. Lee et al., "CYTOTOXIC ACTIVITY AGAINST MAEDI-VISNA VIRUS-INFECTED MACROPHAGES", Journal of virology, 68(12), 1994, pp. 8331-8338

Abstract

The cell type predominantly infected by maedi-visna virus (MVV) is the macrophage, and we have looked at the ability of MVV-infected macrophages to interact with cytotoxic T lymphocytes (CTL), important effector cells against virus infections. MVV-specific CTL precursors were detected, after in vitro culture with MVV antigen and recombinant human interleukin-2, in peripheral blood lymphocytes of all MW-infefted sheep. MVV-infected monocyte-derived macrophages and alveolar macrophages were able to stimulate CTL activity in vitro and were targets far these activated CTL. The major effector cell population using MVV-infectedmacrophage targets was CD8(+) lymphocytes, although another population, lymphokine-activated killer cells, may also have been involved. There was no direct cytotoxic activity found in alveolar lymphocytes fromMVV-infected sheep without lung lesions.

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Documento generato il 16/07/20 alle ore 19:23:44