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Titolo:
ATRIAL-NATRIURETIC-PEPTIDE RESPONSE TO UNILATERAL PULMONARY-ARTERY OCCLUSION
Autore:
AMANO J; SUZUKI A; SUNAMMORI M; SHICHIRI M; MARUMO F;
Indirizzi:
TOKYO MED & DENT UNIV,DEPT CARDIOTHORAC SURG,BUNKYO KU,1-5-45 YASHIMATOKYO 113 JAPAN HOKUSHIN GEN HOSP,DEPT THORAC & CARDIOVASC SURG NAGANO JAPAN TOKYO MED & DENT UNIV,DEPT INTERNAL MED 2,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Chest
fascicolo: 5, volume: 106, anno: 1994,
pagine: 1381 - 1386
SICI:
0012-3692(1994)106:5<1381:ARTUPO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTONOMIC NERVOUS-SYSTEM; CHOLINERGIC AGONISTS; NEURAL CONTROL; HEART-FAILURE; ANF RELEASE; HYPERTENSION; PLASMA; RAT; PRESSURE; HYPOXIA;
Keywords:
ALPHA-ADRENERGIC RECEPTOR; ATRIAL NATRIURETIC PEPTIDES; ATROPINE; AUTONOMIC NERVOUS SYSTEM; BETA-ADRENERGIC RECEPTOR; MUSCARINIC RECEPTOR; UNILATERAL PULMONARY ARTERY OCCLUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Amano et al., "ATRIAL-NATRIURETIC-PEPTIDE RESPONSE TO UNILATERAL PULMONARY-ARTERY OCCLUSION", Chest, 106(5), 1994, pp. 1381-1386

Abstract

To test the hypothesis that neural mechanisms evoked by unilateral pulmonary artery occlusion (UPAO) affect the release of atrial natriuretic peptides (ANP) from the heart, hemodynamics and levels of plasma ANP and cyclic guanosine monophosphate (c-GMP) were studied in 11 patients with lung cancer. The UPAO induced a significant rise in heart rateby 5.3 percent, increased mean pulmonary artery pressure by 31 percent without affecting right atrial pressure, and decreased plasma ANP levels in the coronary sinus by 17.4 percent (p < 0.05) from 202.5 +/- 27.1 pg/ml to 167.2 +/- 27.4 pg/ml. Atropine sulfate (0.04 mg/kg) injection increased the heart rate by 38.2 percent (p < 0.01), reduced the stroke volume index by 25.1 percent, decreased coronary sinus ANP levels from 198.5 +/- 16.4 pg/ml to 124.8 +/- 19.6 pg/ml (p < 0.01), and decreased coronary sinus plasma c-GMP levels from 4.6 +/- 0.5 pmol/ml to 3.1 +/- 0.4 pmol/ml (p < 0.05). After atropine pretreatment, UPAO induced a significant (p < 0.05) increase of 34.8 percent in the coronary sinus ANP level. Thus, it is concluded that in UPAO, the secretion of ANP from the heart is modulated partly by the autonomic nervous system.

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Documento generato il 08/07/20 alle ore 07:45:57