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Titolo:
CHRONIC TENSION-TYPE HEADACHE - AMITRIPTYLINE REDUCES CLINICAL HEADACHE-DURATION AND EXPERIMENTAL PAIN SENSITIVITY BUT DOES NOT ALTER PERICRANIAL MUSCLE-ACTIVITY READINGS
Autore:
GOBEL H; HAMOUZ V; HANSEN C; HEININGER K; HIRSCH S; LINDNER V; HEUSS D; SOYKA D;
Indirizzi:
CHRISTIAN ALBRECHTS UNIV KIEL,DEPT NEUROL,NIEMANNSWEG 147 D-24105 KIEL GERMANY
Titolo Testata:
Pain
fascicolo: 2, volume: 59, anno: 1994,
pagine: 241 - 249
SICI:
0304-3959(1994)59:2<241:CTH-AR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICYCLIC ANTI-DEPRESSANTS; EXTEROCEPTIVE SUPPRESSION; CONTRACTION HEADACHE; BLIND; 5-HYDROXYTRYPTAMINE; PROPHYLAXIS; SEROTONIN; TRIAL;
Keywords:
CHRONIC TENSION-TYPE HEADACHE; AMITRIPTYLINE; PERICRANIAL MUSCLE ACTIVITY; EXTEROCEPTIVE SUPPRESSION; CONTINGENT NEGATIVE VARIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
H. Gobel et al., "CHRONIC TENSION-TYPE HEADACHE - AMITRIPTYLINE REDUCES CLINICAL HEADACHE-DURATION AND EXPERIMENTAL PAIN SENSITIVITY BUT DOES NOT ALTER PERICRANIAL MUSCLE-ACTIVITY READINGS", Pain, 59(2), 1994, pp. 241-249

Abstract

In a double-blind, placebo-controlled trial, the effect of 75 mg of aslow-release formulation of amitriptyline on the clinical severity ofchronic tension-type headache and on headache-associated neurophysiologicaI parameters (EMG activity, exteroceptive suppression of temporalmuscle activity, contingent negative variation (CNV) and experimentalpain sensitivity) was investigated. All of the patients treated had ahistory of headaches of many years' standing and many of them had failed attempts at treatment. In the amitriptyline group, a significant reduction in daily headache duration was already found in the 3rd week of treatment, while in the placebo group no significant changes in headache duration were to be seen. In week 6 the amitriptyline group had a significantly shorter daily duration of headache than did the placebo group. Treatment did not result in any significant effects on EMG recordings of pericranial muscle activity either during relaxation or contraction, on exteroceptive suppression of the temporal muscle and on CNV. The sensitivity to suprathreshold experimental pain, however, wassignificantly reduced. The data show a statistically relevant reduction of daily headache duration. However, they also show that amitriptyline can only partly alleviate chronic headaches but cannot cure them.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:36:16