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Titolo:
SUCKLING-INDUCED CHANGES IN RESPONSIVITY TO THE HYPOALGESIC EFFECT OFMORPHINE
Autore:
WOODSIDE BC; LEE BA; ROCHFORD J;
Indirizzi:
DOUGLAS HOSP,RES CTR,6875 LASALLE BLVD VERDUN H4H 1R3 PQ CANADA CONCORDIA UNIV,CTR STUDIES BEHAV NEUROBIOL,DEPT PSYCHOL MONTREAL H4B 1R6 PQ CANADA MCGILL UNIV,DOUGLAS HOSP,RES CTR,DEPT PSYCHIAT MONTREAL H4H 1R3 PQ CANADA
Titolo Testata:
Pain
fascicolo: 2, volume: 59, anno: 1994,
pagine: 209 - 217
SICI:
0304-3959(1994)59:2<209:SCIRTT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE SECRETION; OPIATE RECEPTOR MECHANISMS; PAIN CONTROL MECHANISMS; INDUCED ANALGESIA; BETA-ENDORPHIN; PROLACTIN-RELEASE; OVARIAN-STEROIDS; LACTATING RATS; SWIM ANALGESIA; ESTROUS-CYCLE;
Keywords:
MORPHINE; LACTATION; SUCKLING; ANTINOCICEPTION; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Woodside et al., "SUCKLING-INDUCED CHANGES IN RESPONSIVITY TO THE HYPOALGESIC EFFECT OFMORPHINE", Pain, 59(2), 1994, pp. 209-217

Abstract

The hypoalgesic effect of morphine in lactating rats was assessed using the hot-plate test. At midlactation (days 12 and 18 postpartum) females nursing litters of 8 pups were less responsive to the hypoalgesiceffect of morphine than ovariectomised or cycling females and femaleson days 6 or 24 of lactation. Subsequent studies showed that the hypoalgesic response to morphine was inhibited in lactating rats at a number of time points after drug administration and across a variety of doses. This effect was not dependent on milk delivery but was dependent on the hormonal state of the female since separation of dams and theirlitters for 96 h was sufficient to reinstate the response to morphineif it resulted in a reappearance of vaginal estrus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 18:16:33