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Titolo:
ANTISECRETORY AND GASTROPROTECTIVE EFFECTS OF AESCINE IN RATS
Autore:
MARHUENDA E; DELALASTRA CA; MARTIN MJ;
Indirizzi:
UNIV SEVILLA,FAC FARM,DEPT FARM & TECHNOL FARMACEUT,PROF GARCIA GONZALEZ S-N E-41012 SEVILLE SPAIN
Titolo Testata:
General pharmacology
fascicolo: 6, volume: 25, anno: 1994,
pagine: 1213 - 1219
SICI:
0306-3623(1994)25:6<1213:AAGEOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-MUCOSAL INJURY; ZINC ACEXAMATE; PROTECTION; GERANYLGERANYLACETONE; INDOMETHACIN; MECHANISMS; MODELS; ACID;
Keywords:
AESCINE; ETHANOL DAMAGE; GASTRIC PROTECTION; GASTRIC ACID SECRETION; PROSTAGLANDINS; MUCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
E. Marhuenda et al., "ANTISECRETORY AND GASTROPROTECTIVE EFFECTS OF AESCINE IN RATS", General pharmacology, 25(6), 1994, pp. 1213-1219

Abstract

1. This study was designed to determine the antisecretory effects of aescine in the perfused stomach of the anaesthetized rat. In addition,the effects of aescine on mucosal lesions produced by intragastric instillation of 1 ml of absolute ethanol, its action on the production of mucus and the possible role of PGs in aescine induced gastroprotection were also studied. 2. Pretreatment of aescine (10 and 50 mg/kg) inhibited the increases in acid secretion induced by histamine (5 mg/kg) and carbachol (10 mu g/kg). At the highest dose used abolished nearly the increase induced by carbachol (P < 0.001).3. Aescine (10, 25 and 50 mg/kg) was found to be effective in the prevention of gastric ulceration induced by absolute ethanol in rats. The degree of gastroprotection decreased with time, the optime effects occurring 60-120 min after oral administration. Pretreatment with indomethacin (10 mg/kg) partially inhibited the gastric protection but the PGE(2) determination did not show an increase in prostanoid levels. Furthermore, the protective effect was not associated with an increase in the amount of gastric mucus and glycoprotein content. 4. These results indicate that aescine exerts an antisecretory action which could play a possible role in its antiulcerogentic activity. Also it shows a marked protective mucosal activity which could be partly explained through non-prostaglandin dependent mechanisms involving its antiinflammatory and vasoactive properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:52:58