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Titolo:
VANADATE TREATMENT REVERSES GASTROINTESTINAL COMPLICATIONS IN THE STREPTOZOTOCIN-DIABETIC RATS
Autore:
OZTURK Y; YILDIZOGLUARI N; PEKINER C; OZCELIKAY AT; ALTAN VM;
Indirizzi:
ANADOLU UNIV,FAC PHARM,DEPT PHARMACOL TEPEBASI 26470 TURKEY ANKARA UNIV,FAC PHARM,DEPT PHARMACOL ANKARA 06100 TURKEY
Titolo Testata:
General pharmacology
fascicolo: 6, volume: 25, anno: 1994,
pagine: 1109 - 1114
SICI:
0306-3623(1994)25:6<1109:VTRGCI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RESPONSES; GASTRIC-ACID SECRETION; SMOOTH-MUSCLE; AUTONOMIC NEUROPATHY; BLOOD-GLUCOSE; GUINEA-PIG; INSULIN; SENSITIVITY; MANAGEMENT; VANADIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ozturk et al., "VANADATE TREATMENT REVERSES GASTROINTESTINAL COMPLICATIONS IN THE STREPTOZOTOCIN-DIABETIC RATS", General pharmacology, 25(6), 1994, pp. 1109-1114

Abstract

1. Insulin-like effects of vanadium compounds have been reported in various experimental conditions. Effects of vanadate on the decreased beta-adrenergic responsiveness of the rat duodenum due to streptozotocin diabetes were investigated to determine its influence on diabetic gastro-intestinal complications as well as its effects on the carbohydrate metabolism. 2. Administration of sodium orthovanadate to streptozoticin-diabetic rats in drinking water (0.7 mg/ml) for 4 weeks resulted in an improvement of carbohydrate metabolism noticed by increased serum levels of insulin and decreased blood levels of glucose as reported in previous studies. 3. Vanadate treatment of streptozotocin-diabetic rats also corrected the diabetic changes in the beta-adrenergic responsiveness of the rat duodenum to salbutamol suggesting a beneficial effect on the diabetic complications of rat gastro-intestinal tract. The same treatment with vanadate did not cause any alteration in the beta-adrenergic responsiveness of isolated duodenum from non-diabetic rats.4. From the findings obtained, it is concluded that vanadate possesses an insulin-like effect on the beta-adrenergic responsiveness of the rat gastro-intestinal tract. Since vanadate treatment did not alter the beta-adrenergic responses of isolated duodenum from non-diabetic rats it seems likely that the insulin-like effect of vanadate is dependent on increased responsiveness of the gastrointestinal tract to circulating insulin.

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Documento generato il 24/09/20 alle ore 10:21:14