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Titolo:
ANTAGONISM OF CLONIDINE INJECTED INTRACEREBROVENTRICULARLY IN DIFFERENT MODELS OF SALT INTAKE
Autore:
SATO MA; YADA MM; RENZI A; CAMARGO LAA; SAAD WA; MENANI JV; DELUCA LA;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 ARARAQUARA SP BRAZIL UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 12, volume: 29, anno: 1996,
pagine: 1663 - 1666
SICI:
0100-879X(1996)29:12<1663:AOCIII>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED SODIUM APPETITE; ANGIOTENSIN-II; ALPHA-2-ADRENERGIC RECEPTORS; RAT; SUBTYPES; BINDING;
Keywords:
SODIUM INTAKE; DEHYDRATION; ADRENOCEPTORS; IDAZOXAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Sato et al., "ANTAGONISM OF CLONIDINE INJECTED INTRACEREBROVENTRICULARLY IN DIFFERENT MODELS OF SALT INTAKE", Brazilian journal of medical and biological research, 29(12), 1996, pp. 1663-1666

Abstract

Clonidine, an alpha 2-adrenergic agonist, injected into the brain inhibits salt intake of animals treated by the diuretic model of sodium depletion. In the present study, we address the question of whether central injection of clonidine also inhibits salt intake in animals deprived of water or in the need-free state. Saline or clonidine (30 nmol) was injected into the anterior third ventricle of 24-h sodium-depleted(furosemide + removal of ambient sodium), of 24-h water-deprived and of normovolemic (need-free state) adult male rats, Clonidine injected intracerebroventricularly (icv) inhibited the 1.5% NaCl intake for 120min by 50 to 90% in every model tested. Therefore, different models of salt intake are inhibited by icv injection of clonidine, Idazoxan, an alpha 2-adrenergic antagonist, injected icy at a dose of 160 nmol, inhibited the effect of clonidine only in the furosemide + removal of ambient sodium model of salt intake. This indicates that the antagonismof this effect by idazoxan is dependent on the body fluid/sodium status of the animal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:24:24