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Titolo:
ANTIHISTONE ANTIBODY PROFILE IN SULFASALAZINE INDUCED LUPUS
Autore:
BRAY VJ; WEST SG; SCHULTZ KT; BOUMPAS DT; RUBIN RL;
Indirizzi:
FITZSIMONS ARMY MED CTR,DEPT MED,RHEUMATOL SERV,HSHG MDR AURORA CO 80045 MED GRP 28,DEPT MED ELLSWORTH AFB SD 00000 NIH BETHESDA MD 20892 SCRIPPS CLIN & RES INST LA JOLLA CA 00000
Titolo Testata:
Journal of rheumatology
fascicolo: 11, volume: 21, anno: 1994,
pagine: 2157 - 2158
SICI:
0315-162X(1994)21:11<2157:AAPISI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOANTIBODIES; CHROMATIN;
Keywords:
DRUG INDUCED LUPUS; ANTIHISTONE ANTIBODIES; SULFASALAZINE; OLSALAZINE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
V.J. Bray et al., "ANTIHISTONE ANTIBODY PROFILE IN SULFASALAZINE INDUCED LUPUS", Journal of rheumatology, 21(11), 1994, pp. 2157-2158

Abstract

Two patients developed drug induced lupus secondary to sulfasalazine (SSZ). One patient was receiving SSZ for Crohn's disease and was subsequently treated with olsalazine, which lacks the sulfapyridine component of SSZ. Her inflammatory bowel disease (IBD) remained controlled and she did not develop a recurrence of lupus, suggesting that olsalazine is safe in patients with IBD and a history of SSZ induced lupus. TheSSZ induced antibodies were predominantly IgG against the (H2A-H2B)-DNA complex. Since lupus induced by 7 other drugs was associated with asimilar antibody response, our findings support the existence of a common pathway for autoantibody induction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:59:51