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Titolo:
THE ACTIVITIES OF 5-BETA-REDUCTASE AND 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN ESSENTIAL-HYPERTENSION
Autore:
IKI K; MIYAMORI I; HATAKEYAMA H; YONEDA T; TAKEDA Y; TAKEDA R; DAI QL;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN BEIJING JIN XIAN QIAO HOSP BEIJING PEOPLES R CHINA
Titolo Testata:
Steroids
fascicolo: 11, volume: 59, anno: 1994,
pagine: 656 - 660
SICI:
0039-128X(1994)59:11<656:TAO5A1>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT MINERALOCORTICOID EXCESS; CORTISOL CORTISONE SHUTTLE; GLYCYRRHETINIC ACID; RAT-KIDNEY; LOCALIZATION; RECEPTOR; DEFICIENCY; GLUCOCORTICOIDS; ALDOSTERONE; METABOLISM;
Keywords:
11-BETA-HYDROXYSTEROID DEHYDROGENASE; 5-BETA-REDUCTASE; ESSENTIAL HYPERTENSION; CORTISOL METABOLISM; GAS CHROMATOGRAPHY MASS SPECTROMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K. Iki et al., "THE ACTIVITIES OF 5-BETA-REDUCTASE AND 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN ESSENTIAL-HYPERTENSION", Steroids, 59(11), 1994, pp. 656-660

Abstract

The activities of 11 beta-hydroxysteroid dehydrogenase(11 beta-HSD) and 5 beta-reductase were analyzed in 39 normotensive controls and 128 patients with essential hypertension. The activity of 11 beta-HSD was obtained by dividing the 24-hour urinary tetrahydrocortisone by the sum of tetrahydrocortisol (THF) and allo-tetrahydrocortisol (aTHF), whereas the activity of 5 beta-reductase was obtained by dividing the 24-hour urinary THF by aTHF. The activity of 5 beta-reductase was significantly lower in essential hypertensives compared with normotensive controls (P < 0.05). However, the activity of 11 beta-HSD did not differ between normotensive controls and essential hypertensives. A positive correlation between the activities of 11 beta-HSD and 5 beta-reductase was observed in essential hypertensives (r = 0.60, P < 0.01). Neither 11 beta-HSD nor 5 beta-reductase activity correlated with indices of renal mineralocorticoid receptor activation, which were assessed by determination of plasma potassium and urinary excretion of sodium as wellas potassium. Taken together, these results suggest that disturbancesof one of the inactivation pathways of cortisol may contribute to thepathogenesis of hypertension.

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Documento generato il 28/11/20 alle ore 23:28:43