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Titolo:
EVALUATION OF INTRA-BLOOD BRAIN BARRIER IGG SYNTHESIS RATE AND BLOOD-BRAIN-BARRIER FUNCTION IN NORMAL RHESUS-MONKEYS
Autore:
JORDAN EK; WOODWARD RA; SHIFERAW Y; BLACK J; SAFAR J;
Indirizzi:
NINCDS,ANIM HLTH & CARE SECT,RM 4A19,BLDG 36 BETHESDA MD 20892
Titolo Testata:
Primates
fascicolo: 4, volume: 35, anno: 1994,
pagine: 473 - 487
SICI:
0032-8332(1994)35:4<473:EOIBBI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; CEREBROSPINAL-FLUID; EVOKED-POTENTIALS; IMMUNE-RESPONSE; LOCAL SYNTHESIS; DISEASES; FORMULA;
Keywords:
BLOOD BRAIN BARRIER (BBB); INTRA-BBB IGG SYNTHESIS; CEREBROSPINAL FLUID (CSF); ALBUMIN; IGG; RHESUS MONKEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E.K. Jordan et al., "EVALUATION OF INTRA-BLOOD BRAIN BARRIER IGG SYNTHESIS RATE AND BLOOD-BRAIN-BARRIER FUNCTION IN NORMAL RHESUS-MONKEYS", Primates, 35(4), 1994, pp. 473-487

Abstract

In order to evaluate blood brain barrier (BBB) integrity and intra-BBB IgG synthesis under CSF pathologic conditions, it is necessary to establish normal values in a control population. In this study an evaluation was made of the blood brain barrier (BBB) integrity and intra-BBBIgG synthesis in the central nervous system (CNS) of normal juvenile rhesus monkeys to establish these values. Parallel cisternal cerebral spinal fluid (CSF) and venous serum samples were collected from 12 healthy male rhesus monkeys. Normal values for CSF/serum ratios of IgG and of albumin were determined and incorporated in the TOURTELLOTTE formula for quantitation of intrathecally synthesized IgG per 24 hours. The effect of systemic mannitol administration on the BBB was also evaluated by the primate adapted formula and magnetic resonance imaging contrast enhanced studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:55:48