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Titolo:
FAST INHIBITION OF INWARDLY RECTIFYING K+ CHANNELS BY MULTIPLE NEUROTRANSMITTER RECEPTORS IN OLIGODENDROGLIA
Autore:
KARSCHIN A; WISCHMEYER E; DAVIDSON N; LESTER HA;
Indirizzi:
MAX PLANCK INST BIOPHYS CHEM D-37077 GOTTINGEN GERMANY CALTECH,DIV BIOL 156-29 PASADENA CA 91125
Titolo Testata:
European journal of neuroscience
fascicolo: 11, volume: 6, anno: 1994,
pagine: 1756 - 1764
SICI:
0953-816X(1994)6:11<1756:FIOIRK>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE MATTER GLIA; LOCUS-CERULEUS NEURONS; SUBSTANCE-P; POTASSIUM CHANNELS; CULTURED OLIGODENDROCYTES; PROGENITOR-CELL; ANGIOTENSIN-II; PATCH-CLAMP; PROTEIN; EXPRESSION;
Keywords:
7-HELIX RECEPTORS; SIGNAL TRANSDUCTION; G PROTEIN; DIRECT GATING; SOMATOSTATIN RECEPTORS; SEROTONIN RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
A. Karschin et al., "FAST INHIBITION OF INWARDLY RECTIFYING K+ CHANNELS BY MULTIPLE NEUROTRANSMITTER RECEPTORS IN OLIGODENDROGLIA", European journal of neuroscience, 6(11), 1994, pp. 1756-1764

Abstract

An essential function of myelinating oligodendroglia in the mammaliancentral nervous system is the regulation of extracellular potassium levels by means of a prominent inwardly rectifying K+ current. Cardiac and neuronal K+ inward rectifiers are either activated by hyperpolarizing voltages or controlled by neurotransmitters through the action of receptor-activated G proteins. Neuromodulation of inward rectifiers has not previously been considered as a way to regulate oligodendrocyte function. Here we report the expression of serotonin, somatostatin andmuscarinic acetylcholine G protein-coupled receptors in rat brain oligodendrocytes. Activation of these receptors leads to pertussis toxin-sensitive inhibition of inwardly rectifying K+ channels within < 1 s. By contrast, in the heart and in neurons, similar pathways activate aninwardly rectifying conductance. Thus, transmitter-mediated blockade of inward rectifiers appears to be an oligodendrocyte-specific variation of a common motif for convergent signalling pathways. In vivo, expression of this mechanism, which may be dependent on neuron-glia signalling, may have a regulatory role in K+ homeostasis during neuron activity in the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 09:12:26