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Titolo:
ENHANCEMENT OF LIVER HEMANGIOMAS ON T1-WEIGHTED MR SE IMAGES BY SUPERPARAMAGNETIC IRON-OXIDE PARTICLES
Autore:
GRANGIER C; TOURNIAIRE J; MENTHA G; SCHIAU R; HOWARTH N; CHACHUAT A; GROSSHOLZ M; TERRIER F;
Indirizzi:
HOP CANTONAL UNIV GENEVA,DIV RADIODIAGNOST,24 RUE MICHELI CREST CH-1211 GENEVA 14 SWITZERLAND UNIV HOSP GENEVA,DEPT RADIOL GENEVA SWITZERLAND UNIV HOSP GENEVA,DEPT SURG GENEVA SWITZERLAND LAB GUERBET AULNAY SOUS BOIS FRANCE
Titolo Testata:
Journal of computer assisted tomography
fascicolo: 6, volume: 18, anno: 1994,
pagine: 888 - 896
SICI:
0363-8715(1994)18:6<888:EOLHOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYNAMIC BOLUS CT; CONTRAST AGENTS; SPLEEN;
Keywords:
HEMANGIOMA; LIVER, NEOPLASMS; MAGNETIC RESONANCE IMAGING, TECHNIQUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
C. Grangier et al., "ENHANCEMENT OF LIVER HEMANGIOMAS ON T1-WEIGHTED MR SE IMAGES BY SUPERPARAMAGNETIC IRON-OXIDE PARTICLES", Journal of computer assisted tomography, 18(6), 1994, pp. 888-896

Abstract

Objective: Superparamagnetic iron oxide (SPIO) particles are phagocytosed by cells of the macrophage-monocytic phagocytic system. They are usually used in MRI as a negative contrast agent, because of their strong T2 effect, to improve detection of tumors in the liver and spleen. However, they also have a potent T1 relaxivity. In the current study, we describe this T1 effect in liver hemangiomas. Materials and Methods: Twelve patients (nine women and three men, aged from 38 to 76 years) with liver hemangiomas were examined by means of MRI at 1.5 T before and after intravenous administration of SPIO particles at a dose of 15 mu mol Fe/kg body wt. Signal intensity was measured from regions ofinterest. Results: Whereas on postcontrast T2-weighted SE images the hemangiomas showed on average a signal drop of 20% (p = 0.011) and 49%(p = 0.001) (first and second echo, respectively), their signal increased by 106% (p = 0.001) on postcontrast TI-weighted SE images. Conclusion: The T1 effect (signal enhancement) we observed in liver hemangiomas after infusion of SPIO particles could prove to be a useful new diagnostic feature that would help characterize these common lesions anddifferentiate them from other liver tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:53:54