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Titolo:
MACROPHAGE-COLONY-STIMULATING FACTOR ENHANCES THE SUSCEPTIBILITY OF MACROPHAGES TO INFECTION BY HUMAN-IMMUNODEFICIENCY-VIRUS AND REDUCES THE ACTIVITY OF COMPOUNDS THAT INHIBIT VIRUS BINDING
Autore:
BERGAMINI A; PERNO CF; DINI L; CAPOZZI M; PESCE CD; VENTURA L; CAPPANNOLI L; FALASCA L; MILANESE G; CALIO R; ROCCHI G;
Indirizzi:
UNIV ROMA TOR VERGATA,DEPT PUBL HLTH & CELLULAR BIOL,CATTEDRA CLIN MALATTIE INFETT I-00173 ROME ITALY UNIV ROMA TOR VERGATA,DEPT EXPTL MED & BIOCHEM SCI I-00173 ROME ITALY UNIV LECCE,DEPT BIOL I-73100 LECCE ITALY
Titolo Testata:
Blood
fascicolo: 10, volume: 84, anno: 1994,
pagine: 3405 - 3412
SICI:
0006-4971(1994)84:10<3405:MFETSO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PERIPHERAL-BLOOD; RECOMBINANT SOLUBLE CD4; AIDS-RELATED COMPLEX; DEXTRAN SULFATE; MONOCYTE MACROPHAGES; BONE-MARROW; LYMPHOCYTES-T; MONONUCLEAR PHAGOCYTES; PERITONEAL-MACROPHAGES; LANGERHANS CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
A. Bergamini et al., "MACROPHAGE-COLONY-STIMULATING FACTOR ENHANCES THE SUSCEPTIBILITY OF MACROPHAGES TO INFECTION BY HUMAN-IMMUNODEFICIENCY-VIRUS AND REDUCES THE ACTIVITY OF COMPOUNDS THAT INHIBIT VIRUS BINDING", Blood, 84(10), 1994, pp. 3405-3412

Abstract

The effects of macrophage colony-stimulating factor (M-CSF) on CD4 receptor expression, susceptibility to human immunodeficiency virus type1 (HIV) infection, and anti-HIV activity of dextran sulfate and soluble-CD4 were studied in cultured, human primary macrophages. M-CSF stimulated macrophage cells to express the CD4 receptor, and this resultedin an increase of both the number of CD4(+) cells and the density of the receptor on the cell surface. M-CSF also significantly enhanced the susceptibility of macrophage cells to HIV infection. Interestingly, the anti-HIV activity of dextran sulfate and soluble-CD4 (two compounds that interfere with HIV-CD4 binding with different mechanisms) was reduced 100-fold and fivefold, respectively, in M-CSF-treated macrophages. Human blood concentrations of M-CSF are reported to be similar to those used in this work (1,000 U/ mL); thus, it is conceivable that also in vivo this cytokine may modify the susceptibility of macrophages to HIV and the ability of dextran sulfate and soluble CD4 to inhibit HIV replication. These results suggest that the in vitro study in M-CSF-treated macrophages of promising drugs inhibitors of HIV-CD4 binding could provide further insights into the potential efficacy of these compounds in patients. (C) 1994 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:02:42