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Titolo:
RENAL VASODILATING AND DIURETIC ACTIONS OF A SELECTIVE ENDOTHELIN ET(B) RECEPTOR AGONIST, IRL1620
Autore:
YUKIMURA T; YAMASHITA Y; MIURA K; KIM S; IWAO H; TAKAI M; OKADA T;
Indirizzi:
OSAKA CITY UNIV,SCH MED,DEPT PHARMACOL,ABENO KU,1-4-54 ASAHIMACHI OSAKA 545 JAPAN CIBA GEIGY CORP,INT RES LABS TAKARAZUKA HYOGO 665 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 264, anno: 1994,
pagine: 399 - 405
SICI:
0014-2999(1994)264:3<399:RVADAO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; L-ARGININE; DOGS; RAT; IBUPROFEN; RESPONSES; CIRCULATION; INHIBITION; IRL-1620; POTENT;
Keywords:
ENDOTHELIN; L-N-G-NITROARGININE; IBUPROFEN; EDRF (ENDOTHELIUM-DERIVED RELAXING FACTOR); RENAL BLOOD FLOW; URINE FLOW RATE; URINE OSMOLALITY; GLOMERULAR FILTRATION RATE; (DOG);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Yukimura et al., "RENAL VASODILATING AND DIURETIC ACTIONS OF A SELECTIVE ENDOTHELIN ET(B) RECEPTOR AGONIST, IRL1620", European journal of pharmacology, 264(3), 1994, pp. 399-405

Abstract

The effects of a selective agonist for endothelin ET(B) receptors, Suc-[Glu(9),Ala(11,15)]endothelin-1-(8-21), IRL1620, on renal hemodynamics and urine formation were studied in anesthetized dogs. Intrarenal arterial infusion of IRL1620 at a dose of 50 ng/kg/min increased renal blood flow from 3.37 +/- 0.30 (mean +/- S.E.) to a maximal value of 4.43 +/- 0.45 ml/g kidney weight per min (ml/g/min) at 9.1 +/- 1.0 min after the start of infusion, with no change in systemic blood pressure and heart rate. Urine now rate increased and urine osmolality, osmolarclearance and free water reabsorption decreased significantly whereasglomerular filtration rate remained unchanged. In dogs given ibuprofen (12.5 mg/kg, i.v.) after the start of infusion of the peptide, renalblood flow increased slightly but significantly from 3.78 +/- 0.82 to4.17 +/- 0.96 ml/g/min (1.0 +/- 0.1 min), followed by a gradual reduction in renal blood flow. In dogs given L-N-G-nitroarginine (75 mu g/kg/min), the renal blood flow decreased following intrarenal administration of IRL1620 (50 ng/kg/min). It is suggested that IRL1620 enhances the release of nitric oxide and prostaglandins in the kidney and promotes renal vasodilation. The IRL1620-induced reduction of urine osmolality and free water reabsorption was affected by neither ibuprofen nor L-N-G-nitroarginine, thereby suggesting that the suppression of urine concentration did not seem to be linked to the enhanced production of nitric oxide or prostaglandins in the kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:55:38