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Titolo:
A CHOLECYSTOKININ RECEPTOR ANTAGONIST, LOXIGLUMIDE, STIMULATES BILIARY-SECRETION IN CONSCIOUS RATS
Autore:
WATANABE N; OTSUKI M;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 3,YAHATANISHI KU,1-1 ISEIGAOKA KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT INTERNAL MED 3,YAHATANISHI KU KITAKYUSHU FUKUOKA 807 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 264, anno: 1994,
pagine: 331 - 336
SICI:
0014-2999(1994)264:3<331:ACRALS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC-SECRETION; HEALTHY-VOLUNTEERS; BILE-FLOW; CCK; L-364,718; HORMONES; CERULEIN; MK-329; HUMANS; GROWTH;
Keywords:
CCK RECEPTOR ANTAGONIST; LOXIGLUMIDE; MK-329; BILE FLOW; BILIRUBIN SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
N. Watanabe e M. Otsuki, "A CHOLECYSTOKININ RECEPTOR ANTAGONIST, LOXIGLUMIDE, STIMULATES BILIARY-SECRETION IN CONSCIOUS RATS", European journal of pharmacology, 264(3), 1994, pp. 331-336

Abstract

The effects of the CCK receptor antagonists loxiglumide -5-(N-3-methoxy-propylpentylamino)-5-oxo-pentanoic acid, CR 1505] and MK-329 [3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl yl)-1H-indole-2-carboxamide, L-364,718], on bile flow were investigated in conscious rats. The bile duct of male Wistar rats was cannulated to directly collect pure bile,and the second cannula was inserted into the duodenum for reinfusion of bile. On the 4th through 7th postoperative days loxiglumide (25, 50or 100 mg/kg body weight), MK-329 (1 mg/kg body weight) or the respective solvent (saline and 80% dimethyl sulfoxide) was injected subcutaneously. Loxiglumide caused dose-dependent increases in bile flow and bile acid output with a slight non-dose-dependent increase in bilirubinoutput. The integrated increments of bile flow during a 3-h period after saline and 100 mg/kg body weight loxiglumide were -14 +/- 71 and 982 +/- 61 mu l/100 g body weight, respectively, and those of bile acids were 2.5 +/- 1.4 and 23.1 +/- 4.1 mu mol/100 g body weight, respectively. In contrast, MK-329 markedly decreased the bile flow (-439 +/- 76 vs. control; -32.8 +/- 76 mu l/100 g body weight/3 h, P < 0.001) andbile acids output (-16.3 +/- 6.8 vs. control; 3.4 +/- 3.8 mu mol/100 g body weight/3 h, P < 0.001); while it significantly increased bilirubin output (86.4 +/- 15.6 vs. 43.5 +/- 1.1 mg/100 g body weight/3 h, P< 0.001). It is concluded that loxiglumide has choleretic effects in rats, whereas MK-329 has opposite effects on bile flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:51:57