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Titolo:
LASER-TISSUE INTERACTION DURING TRANSMYOCARDIAL LASER REVASCULARIZATION
Autore:
JANSEN ED; FRENZ M; KADIPASAOGLU KA; PFEFER TJ; ALTERMATT HJ; MOTAMEDI M; WELCH AJ;
Indirizzi:
VANDERBILT UNIV,DEPT BIOMED ENGN,BOX 1631,STN B NASHVILLE TN 37203 UNIV TEXAS,BIOMED ENGN PROGRAM AUSTIN TX 78712 TEXAS HEART INST HOUSTON TX 77025 UNIV TEXAS,MED BRANCH,BIOMED LASER & SPECT LAB GALVESTON TX 77550 UNIV BERN,INST APPL PHYS CH-3012 BERN SWITZERLAND UNIV BERN,INST PATHOL CH-3012 BERN SWITZERLAND
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 3, volume: 63, anno: 1997,
pagine: 640 - 647
SICI:
0003-4975(1997)63:3<640:LIDTLR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL REVASCULARIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Jansen et al., "LASER-TISSUE INTERACTION DURING TRANSMYOCARDIAL LASER REVASCULARIZATION", The Annals of thoracic surgery, 63(3), 1997, pp. 640-647

Abstract

Background. The clinical procedure known as transmyocardial revascularization has recently seen its renaissance. Despite the promising preliminary clinical results, the associated mechanisms are subject to much discussion. This study is an attempt to unravel the basics of the interaction between 800-W CO2 laser radiation and biological tissue. Methods. Time-resolved flash photography was used to visualize the laser-induced channel formation in water and in vitro porcine myocardium. Inaddition, laser-induced pressures were measured. Light microscopy andbirefringence microscopy were used to assess the histologic characteristics of laser-induced thermal damage. Results. The channel depth increased logarithmically with time (ie, with pulse duration) in water and porcine myocardium. Pressure measurements showed the occurrence of numerous small transients during the laser pulse, which corresponded with channel formation, as well as local and partial channel collapse during the laser pulse. Twenty millimeters of myocardium was perforated in 25 ms. Increasing the pulse duration had a small effect on the maximum transversable thickness, but histologic analysis showed that thermal damage around the crater increased with increasing pulse duration. Conclusions. Several basic aspects of the interaction of high-power CO2 laser radiation with myocardial tissue and tissue phantoms were studied in vitro. Although the goal of this study was not to unravel the mechanisms responsible for the beneficial effects of transmyocardial revascularization, it provided important information on the process of channel formation and collapse and tissue damage. (C) 1997 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:46:46